Jiayang Xie

TL;DR: This study demonstrated that poly(2-oxazoline) based glycine pseudopeptides can mimic host defense peptide and have potent in vitro and in vivo activities against methicillin-resistant Staphylococcus aureus that cause formidable infections.

TL;DR: It is demonstrated that random copolymers of heterochiral poly-β-peptides, without the need for defined secondary structures, can mimic the antimicrobial HDP, implying the potential application of these poly- β-peptic as new antimicrobial agents to tackle drug resistant antimicrobial infections.

TL;DR: In this paper, a ring-opening polymerization of N-substituted N-carboxyanhydrides (NNCA) was used to obtain peptoid polymers with variable C-terminal functional groups.

TL;DR: In vivo study using methicillin-resistant Staphylococcus aureus-pre-incubated TPU-50:50 DM-Hex surfaces for subcutaneous implantation revealed a 3.4-log reduction of MRSA cells after the implantation for 11 days at the surrounding tissue of implanted TPU sheet and significant suppression of infection, compared to bare TPU control.

TL;DR: A 27-mer peptide polymer is reported, as a synthetic mimic of a host defense peptide, that displayed potent in vitro and in vivo activities against multiple strains of clinically isolated MDR Pseudomonas aeruginosa, performing even better than antibiotics within this study.