J
Jicheng Yu
Researcher at University of North Carolina at Chapel Hill
Publications - 92
Citations - 5308
Jicheng Yu is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Medicine & Insulin. The author has an hindex of 31, co-authored 62 publications receiving 3700 citations. Previous affiliations of Jicheng Yu include Durham University & Nanjing University.
Papers
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Journal ArticleDOI
Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery
Jicheng Yu,Yuqi Zhang,Yanqi Ye,Rocco DiSanto,Wujin Sun,Davis Ranson,Frances S. Ligler,John B. Buse,Zhen Gu +8 more
TL;DR: The “smart insulin patch” with a new enzyme-based glucose-responsive mechanism can regulate the blood glucose of type 1 diabetic mice to achieve normal levels, with faster responsiveness compared with the commonly used pH-sensitive formulations, and can avoid the risk of hypoglycemia.
Journal ArticleDOI
Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy
Chenggen Qian,Chenggen Qian,Jicheng Yu,Yu-Lei Chen,Quanyin Hu,Xuanzhong Xiao,Wujin Sun,Chao Wang,Peijian Feng,Qun-Dong Shen,Zhen Gu +10 more
TL;DR: A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen and inducing hypoxide to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy.
Journal ArticleDOI
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs.
Jicheng Yu,Jinqiang Wang,Jinqiang Wang,Yuqi Zhang,Guojun Chen,Guojun Chen,Weiwei Mao,Yanqi Ye,Anna R. Kahkoska,John B. Buse,Robert Langer,Zhen Gu +11 more
TL;DR: It is shown that a single removable transdermal patch, bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabricated via in situ photopolymerization, regulated blood glucose in insulin-deficient diabetic mice and minipigs.
Journal ArticleDOI
H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery
Xiuli Hu,Jicheng Yu,Chenggen Qian,Yue Lu,Anna R. Kahkoska,Zhigang Xie,Xiabin Jing,John B. Buse,Zhen Gu +8 more
TL;DR: In vivo testing indicates that a single patch can regulate glucose levels effectively with reduced risk of hypoglycemia and its kinetics can be modulated by adjusting the concentration of GOx loaded into the microneedles.
Journal ArticleDOI
Polymeric microneedles for transdermal protein delivery.
TL;DR: This review surveys the current design and use of polymeric MNs for transdermal protein delivery and discusses the clinical potential and future translation of MNs.