J
Jie Fan
Researcher at University of Pittsburgh
Publications - 84
Citations - 10766
Jie Fan is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Inflammation & Lung injury. The author has an hindex of 38, co-authored 78 publications receiving 8532 citations. Previous affiliations of Jie Fan include Veterans Health Administration.
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Journal ArticleDOI
Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.
TL;DR: High mobility group box 1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either active release from cells, or passive release upon lytic cell death.
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Pattern recognition receptor-dependent mechanisms of acute lung injury.
Meng Xiang,Jie Fan +1 more
TL;DR: An overview of the PRR-dependent mechanisms of ALI and clinical implication is provided and modification of PRR pathways is likely to be a logical therapeutic target for ALI/acute respiratory distress syndrome.
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Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS
Jie Yang,Jie Yang,Yanfeng Zhao,Peng Zhang,Yuehua Li,Yuehua Li,Yong Yang,Yong Yang,Yang Yang,Junjie Zhu,Xiao Song,Gening Jiang,Jie Fan +12 more
TL;DR: A novel mechanism underlying HS-primed ALI is explored and thus presents a potential therapeutic target for post-HS ALI, which significantly exaggerates lung inflammation and injury.
Journal ArticleDOI
IL-36γ transforms the tumor microenvironment and promotes type 1 lymphocyte-mediated antitumor immune responses
Xuefeng Wang,Xin Zhao,Chao Feng,Aliyah M. Weinstein,Rui Xia,Wen Wen,Quansheng Lv,Shuting Zuo,Peijun Tang,Xi Yang,Xiaojuan Chen,Hong-Rui Wang,Shayang Zang,Shayang Zang,Lindsay Stollings,Timothy L. Denning,Jingting Jiang,Jie Fan,Guangbo Zhang,Xueguang Zhang,Yibei Zhu,Walter J. Storkus,Binfeng Lu +22 more
TL;DR: A role of IL-36γ in promoting antitumor immune responses is established and its potential clinical translation into cancer immunotherapy is suggested.
Journal ArticleDOI
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation.
TL;DR: TLR2 expression in AMphi, signaled by TLR4 and regulated by shock-activated PMN, is an important positive-feedback mechanism responsible for shock-primed PMN infiltration into the lung after primary PMN sequestration.