J
Jie Fan
Researcher at University of Pittsburgh
Publications - 84
Citations - 10766
Jie Fan is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Inflammation & Lung injury. The author has an hindex of 38, co-authored 78 publications receiving 8532 citations. Previous affiliations of Jie Fan include Veterans Health Administration.
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Journal ArticleDOI
Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis
Yan Geng,Qiang Ma,Yanan Liu,Na Peng,Fang-Fang Yuan,Fang-Fang Yuan,Xing-Gui Li,Ming Li,Ying-Song Wu,Bing-ling Li,Wei-bing Song,Wei Zhu,Weiwen Xu,Jie Fan,Lei Su +14 more
TL;DR: These findings demonstrate an important role of HMGB1 in mediating inflammasome activation in the development of liver injury following HS, and suggest that targeting inflammaome may represent a novel therapeutic strategy to limit cell death and prevent liver failure after HS.
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Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
Linsong Chen,Yanfeng Zhao,Dengming Lai,Peng Zhang,Yang Yang,Yuehua Li,Ke Fei,Gening Jiang,Jie Fan +8 more
TL;DR: It is shown that NET-derived HMGB1, acting through RAGE and dynamin-dependent signaling, triggers an intra-Mϕ cascade of molecular events including cathepsin B (CatB) release from the ruptured lysosomes, followed by pyroptosome formation and caspase-1 activation, and subsequent Mϕ pyroPTosis.
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Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis
Chuanyue Wu,Hongli Jiao,Yumei Lai,Wei Zheng,Ka Chen,Hong Qu,Weimin Deng,Pingping Song,Ke Zhu,Huiling Cao,Deborah L. Galson,Jie Fan,Hee Jeong Im,Yujie Liu,Ju Chen,Di Chen,Guozhi Xiao +16 more
TL;DR: A previously unrecognized function for Kindlin-2 is uncovered and a mechanism for regulation of the chondrocyte differentiation programme and chondrogenesis is found, resulting in progressive dwarfism and kyphosis in mice.
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Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone.
TL;DR: It is concluded that activation of MCP-1/CCR2 axis promotes PCa growth in bone and suggests that M CP-1 may be a target for PCa progression.
Journal ArticleDOI
TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism
Xingying He,Yongbing Qian,Zhigang Li,Erica K. Fan,Yuehua Li,Yuehua Li,Liang Wu,Liang Wu,Timothy R. Billiar,Mark Wilson,Mark Wilson,Xueyin Shi,Xueyin Shi,Jie Fan,Jie Fan +14 more
TL;DR: A novel mechanism underlying LPS-induced innate immunity is demonstrated, that is, a secondary upregulation of IL-1β-IL-1RI signaling is responsible for AM pyroptosis and augmented lung injury in response to LPS.