Jie Fan

TL;DR: Targeting autophagy‐promoted NETs may present a therapeutic strategy to improve infection defence in an aged population and suggest an important role of Atg5 and autophagic in maintaining the function of NETs formation in response to infection and in regulating neutrophil death.

TL;DR: Zhang et al. as mentioned in this paper identified HSPC111 was the leading upregulated gene in hepatic stellate cells (HSCs) incubated with CRC cell-derived exosomes.

TL;DR: It is demonstrated that the proliferation of HSCs is critically dependent on glutamine that is used to generate α-ketoglutarate (α-KG) and non-essential amino acid (NEAA) and that strategies that are targeted at glutamine metabolism may represent a novel therapeutic approach to the treatment of liver fibrosis.

TL;DR: Findings define a novel mechanism responsible for the anti‐inflammatory effects of hypertonic saline and also suggest a potential clinical role for hyperosmolar solutions in the prevention of liver injury associated with I/R.

TL;DR: It is demonstrated that HS initiates high mobility group box 1/TLR4 signaling, which upregulates NOD2 expression in AMϕ and sensitizes them to subsequent N OD2 ligand muramyl dipeptide to augment lung inflammation, and that HS-activated PMNs that migrate in alveoli counteract the anti-inflammatory effect of autophagy.