Jie Fan

TL;DR: It is established that Foxo1 is a novel negative regulator of osteoblast-specific transcription factor Runx2 and modulates IGF1/insulin-dependent regulation of osteocalcin expression in osteoblasts.

TL;DR: Induction of TLR2 surface expression in lung ECs, induced by HS and mediated by HMGB1/TLR4 signaling, is an important mechanism responsible for endothelial cell-mediated inflammation and organ injury following trauma and hemorrhage.

TL;DR: NET components were significantly increased in response to treatment with septic shock patient-derived exosomes and correlated positively with disease severity and outcome, which suggests a previously unidentified role of platelet-derivedExosomes in sepsis and may lead to new therapeutic approaches.

TL;DR: It is shown that the increased ILC2 in the lungs secrete IL-9, which in turn prevents lung EC from undergoing pyroptosis, a pro-inflammatory cell death form, by attenuating caspase-1 activation, suggesting a previously unidentified innate pathway that negatively regulates lung inflammation following sepsis.

TL;DR: A previous unidentified protective role of damage- associated molecular pattern (DAMP) molecules in restricting inflammation in response to exogenous pathogen-associated molecular pattern molecules is revealed.