J
Jie Li
Researcher at South China University of Technology
Publications - 8
Citations - 400
Jie Li is an academic researcher from South China University of Technology. The author has contributed to research in topics: Nanocarriers & Drug delivery. The author has an hindex of 7, co-authored 8 publications receiving 267 citations. Previous affiliations of Jie Li include Hefei University of Technology & Chinese Academy of Sciences.
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Journal ArticleDOI
ROS-sensitive thioketal-linked polyphosphoester-doxorubicin conjugate for precise phototriggered locoregional chemotherapy
TL;DR: Phototriggered prodrug release and activation at the desired site significantly enhanced the therapeutic efficacy and minimized the side effect, providing new avenues to develop drug delivery systems for remote on-demand drug delivery in vivo.
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Photoinduced PEG deshielding from ROS-sensitive linkage-bridged block copolymer-based nanocarriers for on-demand drug delivery
Jie Li,Chun-Yang Sun,Wei Tao,Ziyang Cao,Haisheng Qian,Xianzhu Yang,Xianzhu Yang,Jun Wang,Jun Wang +8 more
TL;DR: It is demonstrated that the high PEGylation of TK-NPCe6&PTX in blood helps the nanocarrier efficiently avoid rapid clearance and consequently prolongs its circulation time, and this strategy of photoinducing PEG deshielding ofnanocarriers could potentially extend to a variety of therapeutic agents beyond anticancer drugs for on-demand delivery.
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Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis
Haiqiang Cao,Hong Wang,Xinyu He,Tao Tan,Haiyan Hu,Zhiwan Wang,Jing Wang,Jie Li,Zhiwen Zhang,Yaping Li,Yaping Li +10 more
TL;DR: A bioengineered macrophage-based delivery system that can be preferentially delivered to lung metastases and intelligently transformed into nanovesicle and secondary nanovesicles for antimetastasis therapy is reported.
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Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9+ T cells
Hongmei Chen,Xiuxiu Cong,Chenxi Wu,Xuan Wu,Jialiang Wang,Kuirong Mao,Jie Li,Ge Zhu,Feiqi Liu,Xiandi Meng,Jia Song,Xu Sun,Xin Wang,Shuhan Liu,Shi Zhang,Xianzhu Yang,Yanqiu Song,Yong-Guang Yang,Tianmeng Sun +18 more
TL;DR: It is found that CCL25, the only chemokine for CCR9+ cells, is not expressed in human or murine triple-negative breast cancers (TNBCs), raising a hypothesis that intratumoral delivery of CCL 25 may enhance antitumor immunotherapy in TNBCs.
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Acetal-Linked Hyperbranched Polyphosphoester Nanocarriers Loaded with Chlorin e6 for pH-Activatable Photodynamic Therapy.
TL;DR: Treatment with a novel hyperbranched polyphosphoester containing numerous acetal bonds noticeably enhanced the PDT therapeutic efficacy, indicating that such a pH-sensitive hbPPE nanocarrier has great potential to improve the PDT medical efficacy for cancer therapy.