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Xiuxiu Cong
Researcher at Jilin University
Publications - 13
Citations - 169
Xiuxiu Cong is an academic researcher from Jilin University. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 5, co-authored 5 publications receiving 67 citations.
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Journal ArticleDOI
Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib.
Xu Sun,Ziyang Cao,Kuirong Mao,Chenxi Wu,Hongmei Chen,Jialiang Wang,Xin Wang,Xiuxiu Cong,Li Yong,Xianying Meng,Xianzhu Yang,Yong-Guang Yang,Tianmeng Sun +12 more
TL;DR: A rapidly released sorafenib acts synergistically with the low-dose PDT to inhibit tumor growth by inducing strong T cell-dependent local and systemic antitumor immune responses, reprograming the tumor immune microenvironment, and limiting the interaction between cytotoxic CD8+ T cells and immunosuppressive cells.
Journal ArticleDOI
Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9+ T cells
Hongmei Chen,Xiuxiu Cong,Chenxi Wu,Xuan Wu,Jialiang Wang,Kuirong Mao,Jie Li,Ge Zhu,Feiqi Liu,Xiandi Meng,Jia Song,Xu Sun,Xin Wang,Shuhan Liu,Shi Zhang,Xianzhu Yang,Yanqiu Song,Yong-Guang Yang,Tianmeng Sun +18 more
TL;DR: It is found that CCL25, the only chemokine for CCR9+ cells, is not expressed in human or murine triple-negative breast cancers (TNBCs), raising a hypothesis that intratumoral delivery of CCL 25 may enhance antitumor immunotherapy in TNBCs.
Journal ArticleDOI
Cationic Liposome/DNA Complexes Mediate Antitumor Immunotherapy by Promoting Immunogenic Tumor Cell Death and Dendritic Cell Activation
Xiuxiu Cong,Huimin Tian,Shuhan Liu,Kuirong Mao,Hongmei Chen,Yanbao Xin,Feiqi Liu,Xin Wang,Xiandi Meng,Ge Zhu,Jialiang Wang,Xue Gao,Huizhu Tan,Yong-Guang Yang,Tianmeng Sun +14 more
TL;DR: Both the local tumor growth and the distant tumor formation were significantly inhibited by T cell-dependent antitumor immune responses after intratumoral injection of CLN/DNA.
Journal ArticleDOI
Intratumoral delivery of M-CSF by calcium crosslinked polymer micelles enhances cancer immunotherapy
Kuirong Mao,Xiuxiu Cong,Liangzhu Feng,Hongmei Chen,Jialiang Wang,Chenxi Wu,Kun Liu,Chunsheng Xiao,Yong-Guang Yang,Tianmeng Sun +9 more
TL;DR: A tumor acidity-responsive biomacromolecule delivery system was designed to intratumorally deliver an immune-activating cytokine, macrophage colony-stimulating factor (M-CSF) and attenuate the acidic microenvironment and inhibited tumor growth.
Journal ArticleDOI
An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy.
Shuhan Liu,Ji Liu,Hai Song Li,Kuirong Mao,Haorui Wang,Xiandi Meng,Jialiang Wang,Chenxi Wu,Hongmei Chen,Xin Wang,Xiuxiu Cong,Yue Hou,Ye Wang,Ming Wang,Yonggang Yang,Tianmeng Sun +15 more
TL;DR: In this article , a new cationic lipid nanoparticle (LNP) that can efficiently deliver siRNA across the blood-brain barrier (BBB) and target mouse brain is prepared for modulating the tumor microenvironment for GBM immunotherapy.