J
Jie Wen
Researcher at Johns Hopkins University
Publications - 8
Citations - 1346
Jie Wen is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Chemistry & In situ polymerization. The author has an hindex of 6, co-authored 6 publications receiving 1293 citations. Previous affiliations of Jie Wen include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Sustained release of proteins from electrospun biodegradable fibers.
TL;DR: This study investigated the feasibility of encapsulating human beta-nerve growth factor (NGF), which was stabilized in a carrier protein, bovine serum albumin (BSA) in a copolymer of epsilon-caprolactone and ethyl ethylene phosphate (PCLEEP) by electrospinning to produce biofunctional tissue scaffolds.
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The effect of the degree of chitosan deacetylation on the efficiency of gene transfection.
TL;DR: The decreased degree of deacetylation results in a decrease in overall luciferase expression levels in HEK293, HeLa, and SW756 cells due to particle destabilization in the presence of serum proteins, however, intramuscular luciferases expression levels increased with decreasing de acetylation over the time points tested.
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Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold.
Kian-Ngiap Chua,Wei-Seng Lim,Peng-Chi Zhang,Hong-Fang Lu,Jie Wen,Seeram Ramakrishna,Kam W. Leong,Kam W. Leong,Hai-Quan Mao +8 more
TL;DR: Hepatocytes cultured on the galactosylated PCLEEP nanofiber scaffold exhibited similar functional profiles in terms of cell attachment, ammonia metabolism, albumin secretion and cytochrome P450 enzymatic activity as those on the functional 2-D substrate, although their morphologies are different.
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Poly(d,llactide–co-ethyl ethylene phosphate)s as new drug carriers
TL;DR: Copolymers of PLA and poly(ethylethylene phosphate) (PEEP) were synthesized by ring-opening polymerization using Al(Oipr)3 as the initiator and showed low toxicity in HeLa cells and good tissue biocompatibility in mouse brain, respectively.
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Biodegradable polyphosphoester micelles for gene delivery
TL;DR: In vivo studies showed a luciferase expression by PCEP/DNA complexes in muscle increasing with time during 3 months, although the expression level was lower than that by direct injection of naked DNA.