Jill O. Fuss

TL;DR: A collection of 59 vectors that comprise an integrated system for constitutive or inducible expression of cDNAs, shRNAs or miRNAs, and use a wide variety of drug selection markers based on the Gateway technology are described.

TL;DR: In this paper, the crystal structures of the XPD catalytic core were determined from Sulfolobus acidocaldarius and measured mutant enzyme activities, which provided a foundation for understanding disease consequences of mutations in XPD and related 4Fe-4S helicases including FancJ.

TL;DR: Striking advances are examined that uncover Fe-S cluster roles both in copying the genetic sequence by DNA polymerases and in crucial repair processes for genome maintenance, as mutational defects cause cancer and degenerative disease.

TL;DR: The structural biology of DNA damage recognition by XPC-RAD23B, DDB1/DDB2, RNAPII, and ATL, and of helix unwinding by the XPB and XPD helicases plus the bacterial repair helicases UvrB and UvrD in complex with DNA are considered.

TL;DR: AFM data indicate a general link between the ability of a repair protein to carry out DNA CT and its ability to redistribute onto DNA strands near lesions and provide evidence for coordinated DNA CT between different repair proteins in their search for damage in the genome.