F
Francis Rodier
Researcher at Université de Montréal
Publications - 70
Citations - 13103
Francis Rodier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Senescence & DNA damage. The author has an hindex of 28, co-authored 66 publications receiving 10742 citations. Previous affiliations of Francis Rodier include Erasmus University Medical Center & Buck Institute for Research on Aging.
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Journal ArticleDOI
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe,Christopher K. Patil,Francis Rodier,Francis Rodier,Yun-Yu Sun,Denise P. Muñoz,Denise P. Muñoz,Joshua Goldstein,Peter S. Nelson,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +12 more
TL;DR: A cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment is suggested.
Journal ArticleDOI
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier,Jean-Philippe Coppe,Christopher K. Patil,Wieteke A. M. Hoeijmakers,Wieteke A. M. Hoeijmakers,Denise P. Muñoz,Saba R. Raza,Adam Freund,Adam Freund,Eric Campeau,Eric Campeau,Albert R. Davalos,Judith Campisi,Judith Campisi +13 more
TL;DR: In addition to orchestrating cell-cycle checkpoints and DNA repair, a new and important role of the DDR is to allow damaged cells to communicate their compromised state to the surrounding tissue.
Journal ArticleDOI
Four faces of cellular senescence
TL;DR: The challenge now is to understand the senescence response well enough to harness its benefits while suppressing its drawbacks.
Journal ArticleDOI
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Marco Demaria,Naoko Ohtani,Sameh A. Youssef,Francis Rodier,Wendy Toussaint,James R. Mitchell,Remi-Martin Laberge,Jan Vijg,Harry van Steeg,Martijn E.T. Dollé,Jan H.J. Hoeijmakers,Alain de Bruin,Eiji Hara,Judith Campisi,Judith Campisi +14 more
TL;DR: It is shown that senescent fibroblasts and endothelial cells appear very early in response to a cutaneous wound, where they accelerate wound closure by inducing myofibroblast differentiation through the secretion of platelet-derived growth factor AA (PDGF-AA).
Journal ArticleDOI
A versatile viral system for expression and depletion of proteins in mammalian cells.
Eric Campeau,Victoria E. Ruhl,Francis Rodier,Francis Rodier,Carolyn L. Smith,Brittany L. Rahmberg,Jill O. Fuss,Judith Campisi,Judith Campisi,Paul Yaswen,Priscilla K. Cooper,Paul D. Kaufman +11 more
TL;DR: A collection of 59 vectors that comprise an integrated system for constitutive or inducible expression of cDNAs, shRNAs or miRNAs, and use a wide variety of drug selection markers based on the Gateway technology are described.