Jin-Chen Yu

TL;DR: It is shown that in COS-7 cells, activated Ras effectively stimulates MAPK but poorly induces JNK activity, which strongly support a critical role for Rac1 and Cdc42 in controlling the JNK signaling pathway.

TL;DR: It is found that intestinal, but not vascular, MHC mRNA contains an insert of 21 nucleotides, encoding 7 amino acids, in a region near the ATP binding site in the myosin head, suggesting that the 7-amino acid MHC insert is responsible for the different enzymatic activities of vascular and intestinal myosins.

TL;DR: It is concluded that alpha PDGF receptor-associated PI-3 kinase activity is not required for either of these major PDGF signalling functions.

TL;DR: Findings argue that initial PDGF-AB interaction with the alpha PDGFR induces conformational changes in the ligand or receptor that facilitates efficient recruitment of betaPDGFR by this PDGF isoform.

TL;DR: Exposure of PKC-δWT transfectants to TPA induced 32D monocytic differentiation, the 32D/PKC- δK376R transfectantes were resistant to Tpa-induced differentiation, suggesting that expression of active PKC -δ is required to mediate 32DMonocytic differentiated differentiation in response to T PA stimulation.