A
Alexander Ploss
Researcher at Princeton University
Publications - 153
Citations - 10377
Alexander Ploss is an academic researcher from Princeton University. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 46, co-authored 134 publications receiving 8935 citations. Previous affiliations of Alexander Ploss include Imperial College London & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
Alexander Ploss,Matthew J. Evans,Matthew J. Evans,V. Gaysinskaya,Maryline Panis,Hana You,Ype P. de Jong,Ype P. de Jong,Charles M. Rice +8 more
TL;DR: It is shown that human occludin (OCLN) is an essential HCV cell entry factor that is able to render murine cells infectable with HCVpp and the identification of OCLN as a new HCV entry factor further highlights the importance of the tight junction complex in the viral entry process.
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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Florian Klein,Ariel Halper-Stromberg,Joshua A. Horwitz,Henning Gruell,Henning Gruell,Johannes F. Scheid,Johannes F. Scheid,Stylianos Bournazos,Hugo Mouquet,Linda Spatz,Linda Spatz,Ron Diskin,Alexander Abadir,Trinity Zang,Marcus Dorner,Eva Billerbeck,Rachael N. Labitt,Christian Gaebler,Christian Gaebler,Paola Marcovecchio,Reha Baris Incesu,Thomas Eisenreich,Paul D. Bieniasz,Paul D. Bieniasz,Michael S. Seaman,Pamela J. Bjorkman,Jeffrey V. Ravetch,Alexander Ploss,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV- 1-infected individuals.
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Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
Brett D. Lindenbach,Philip Meuleman,Alexander Ploss,Thomas Vanwolleghem,Andrew J. Syder,Jane A. McKeating,Robert E. Lanford,Stephen M. Feinstone,Marian E. Major,Geert Leroux-Roels,Charles M. Rice +10 more
TL;DR: It is reported here that HCVcc strain FL-J6/JFH can establish long-term infections in chimpanzees and in mice containing human liver grafts, and virus recovered from these animals was highly infectious in cell culture, demonstrating efficient ex vivo culture of HCV.
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A genetically humanized mouse model for hepatitis C virus infection
Marcus Dorner,Joshua A. Horwitz,Justin B. Robbins,Walter T. Barry,Qian Feng,Kathy Mu,Christopher T. Jones,John W. Schoggins,Maria Teresa Catanese,Dennis R. Burton,Dennis R. Burton,Mansun Law,Charles M. Rice,Alexander Ploss +13 more
TL;DR: It is demonstrated that HCV can be blocked by passive immunization, as well as showing that a recombinant vaccinia virus vector induces humoral immunity and confers partial protection against heterologous challenge.
Journal ArticleDOI
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
Erick Giang,Marcus Dorner,Jannick Prentoe,Marlène Dreux,Marlène Dreux,Matthew J. Evans,Jens Bukh,Charles M. Rice,Alexander Ploss,Dennis R. Burton,Dennis R. Burton,Mansun Law +11 more
TL;DR: The mAb panel will be useful for the design and development of vaccine candidates to elicit broadly neutralizing antibodies to HCV, and has an exceptionally broad neutralizing activity toward diverse HCV genotypes and protects against heterologous HCV challenge in a small animal model.