J
Jinhong Liu
Researcher at University of Michigan
Publications - 9
Citations - 1602
Jinhong Liu is an academic researcher from University of Michigan. The author has contributed to research in topics: Nephrotic syndrome & Congenital nephrotic syndrome. The author has an hindex of 8, co-authored 8 publications receiving 1498 citations.
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Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Bernward Hinkes,Roger C. Wiggins,Rasheed Gbadegesin,Christopher N. Vlangos,Dominik Seelow,Gudrun Nürnberg,Puneet Garg,Rakesh Verma,Hassan Chaib,Bethan E. Hoskins,Shazia Ashraf,Christian Becker,Hans Christian Hennies,Meera Goyal,Bryan L. Wharram,Asher D. Schachter,Sudha Mudumana,Iain A. Drummond,Dontscho Kerjaschki,Rüdiger Waldherr,Alexander Dietrich,Fatih Ozaltin,Aysin Bakkaloglu,Roxana Cleper,Roxana Cleper,Lina Basel-Vanagaite,Lina Basel-Vanagaite,Martin Pohl,Martin Griebel,Alexey N. Tsygin,Alper Soylu,Dominik N. Müller,Caroline S. Sorli,Tom D. Bunney,Matilda Katan,Jinhong Liu,Massimo Attanasio,John F. O'Toole,Katrin Hasselbacher,Bettina E. Mucha,Edgar A. Otto,Rannar Airik,Andreas Kispert,Grant G. Kelley,Alan V. Smrcka,Thomas Gudermann,Lawrence B. Holzman,Peter Nürnberg,Friedhelm Hildebrandt +48 more
TL;DR: These findings, together with the zebrafish model of human nephrotic syndrome generated by plce1 knockdown, open new inroads into pathophysiology and treatment mechanisms of nephrotsic syndrome.
Journal ArticleDOI
Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2).
Bernward Hinkes,Bettina E. Mucha,Christopher N. Vlangos,Rasheed Gbadegesin,Jinhong Liu,Katrin Hasselbacher,Daniela Hangan,Fatih Ozaltin,Martin Zenker,Friedhelm Hildebrandt +9 more
TL;DR: In this article, a large European cohort of 89 children from 80 families with nephrotic syndrome manifesting in the first year of life and characterized genotype/phenotype correlations was analyzed.
Nephrotic Syndrome in the First Year of Life: Two Thirds of Cases Are Caused by Mutations in 4 Genes
Bernward Hinkes,Bettina E. Mucha,Christopher N. Vlangos,Rasheed Gbadegesin,Jinhong Liu,Daniela Hangan,Fatih Ozaltin,Martin Zenker,Friedhelm Hildebrandt +8 more
TL;DR: Two thirds of nephrotic syndrome manifesting in the first year of life can be explained by mutations in 4 genes only (NPHS1, NPHS2, WT1, or LAMB2); therefore, unnecessary treatment attempts can be avoided.
Journal ArticleDOI
Mutations in PLCE1 are a Major Cause of Isolated Diffuse Mesangial Sclerosis (IDMS)
Rasheed Gbadegesin,Bernward Hinkes,Bethan E. Hoskins,Christopher N. Vlangos,Saskia F. Heeringa,Jinhong Liu,Chantal Loirat,Fatih Ozaltin,Seema Hashmi,Francis Ulmer,Roxanna Cleper,Robert B. Ettenger,Corinne Antignac,Roger C. Wiggins,Martin Zenker,Friedhelm Hildebrandt +15 more
TL;DR: PLCE1 mutation is the most common cause of IDMS in this cohort of 1368 children with NS and mutations in PLCE1 may serve as a biomarker for selecting patients with IDMS who may benefit from treatment.
Journal ArticleDOI
Specific Podocin Mutations Correlate with Age of Onset in Steroid-Resistant Nephrotic Syndrome
Bernward Hinkes,Christopher N. Vlangos,Saskia F. Heeringa,Bettina E. Mucha,Rasheed Gbadegesin,Jinhong Liu,Katrin Hasselbacher,Fatih Ozaltin,Friedhelm Hildebrandt +8 more
TL;DR: In this paper, a worldwide cohort of 430 patients from 404 different families with SRNS were screened by direct sequencing, and the authors found that the majority of those affected by truncating or homozygous R138Q mutations developed nephrotic syndrome before 6 years of age.