Jinxia Wu

TL;DR: The underlying mechanisms of BPA-induced multi-organ toxicity were well summarized, involving the receptor pathways, disruption of neuroendocrine system, inhibition of enzymes, modulation of immune and inflammatory responses, as well as genotoxic and epigenetic mechanisms.

TL;DR: Investigating unexplored molecular pathways by which oxidative stress acts on microcystin-leucine arginine-induced endoplasmic reticulum stress (ERs) and autophagy suggests that oxidative stress plays an important role in female toxicity induced by MC-LR.

TL;DR: The present study indicated that the administration of RES could ameliorate MC-LR-induced Sertoli–germ cell apoptosis and protect against reproductive toxicity in rats by stimulating the SIRT1/p53 pathway, suppressing p53 and Ku70 acetylation and enhancing the binding of Ku70 to Bax.

TL;DR: The damage to the gastrointestinal tract due to MCs was summarized from different aspects, which can be used as a foundation for further exploration of molecular damage mechanisms.

TL;DR: Results indicated that MC-LR could activate the mitochondrial apoptotic pathway and disorder the cell cycle pathway to induce the cell apoptosis by enhancing HDAC activity and reducing histone acetylation of normal testicular cells in SD rats, which provides a new insight on the reproductive toxicity of male induced byMC-LR.