J
Jisong Cui
Researcher at University of Michigan
Publications - 7
Citations - 712
Jisong Cui is an academic researcher from University of Michigan. The author has contributed to research in topics: Factor V & Prothrombinase. The author has an hindex of 6, co-authored 7 publications receiving 693 citations.
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Journal ArticleDOI
Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V.
TL;DR: It is reported here that approximately half of homozygous embryos deficient in factor V (Fv−/−), which have been generated by gene targeting, die at embryonic day (E) 9–10, possibly as a result of an abnormality in the yolk-sac vasculature.
Journal ArticleDOI
Prothrombotic phenotype of protein Z deficiency
Zheng Feng Yin,Zhong Fu Huang,Jisong Cui,Ryan Fiehler,Nina M. Lasky,David Ginsburg,George J. Broze +6 more
TL;DR: The presence of PZ dampens the coagulation response in human plasma and that concomitant PZ deficiency dramatically increases the severity of the prothrombotic phenotype of factor V(Leiden) mice, indicating that PZ plays a physiologically important role in the regulation of coagulations.
Journal ArticleDOI
Spontaneous thrombosis in mice carrying the factor V Leiden mutation.
Jisong Cui,Daniel T. Eitzman,Daniel T. Eitzman,Daniel T. Eitzman,Randal J. Westrick,Randal J. Westrick,Randal J. Westrick,Patricia D. Christie,Patricia D. Christie,Patricia D. Christie,Zuojun J. Xu,Zuojun J. Xu,Zuojun J. Xu,Angela Y. Yang,Angela Y. Yang,Angela Y. Yang,Anjali A. Purkayastha,Anjali A. Purkayastha,Anjali A. Purkayastha,Tony L. Yang,Tony L. Yang,Tony L. Yang,Alan L. Metz,Alan L. Metz,Alan L. Metz,Kim P. Gallagher,Kim P. Gallagher,Kim P. Gallagher,Julia Tyson,Julia Tyson,Julia Tyson,Robert D. Rosenberg,Robert D. Rosenberg,Robert D. Rosenberg,David Ginsburg,David Ginsburg,David Ginsburg +36 more
TL;DR: Results may explain the high degree of conservation of the R504/R506 activated protein C cleavage site within FV among mammalian species and suggest an important contribution of other genetic factors to the thrombosis associated with FVL in humans.
Journal ArticleDOI
Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma
TL;DR: It is demonstrated that wide variations of host PAI-1 expression, from complete absence to marked overexpression, does not significantly influence the metastatic potential of B16 melanoma cells in a murine model.
Journal ArticleDOI
The Structure and Function of Murine Factor V and Its Inactivation by Protein C
Tony L. Yang,Jisong Cui,Alnawaz Rehumtulla,Angela Yang,Micheline Moussalli,Randal J. Kaufman,David Ginsburg +6 more
TL;DR: The structure and function of FV and its interaction with APC are highly conserved across mammalian species, and wild-type and all three mutant FV recombinant proteins show equivalent FV procoagulant activity.