J
Joachim G.J.V. Aerts
Researcher at Erasmus University Rotterdam
Publications - 366
Citations - 19989
Joachim G.J.V. Aerts is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 46, co-authored 319 publications receiving 14585 citations. Previous affiliations of Joachim G.J.V. Aerts include Cancer Institute & Erasmus University Medical Center.
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Journal ArticleDOI
Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.
Dean A. Fennell,Paul Baas,Paul Taylor,Anna K. Nowak,David Gilligan,Takashi Nakano,Jonathan A. Pachter,David T. Weaver,Arnaud Scherpereel,Nick Pavlakis,Jan P. van Meerbeeck,Susana Cedrés,Luke Nolan,Hedy L. Kindler,Joachim G.J.V. Aerts +14 more
TL;DR: Neither PFS nor OS was improved by defactinib after first-line chemotherapy in patients with merlin-low MPM, and defact inib cannot be recommended as maintenance therapy for advanced MPM.
Journal ArticleDOI
Expiratory time constants in mechanically ventilated patients with and without COPD.
M. S. Lourens,B. van den Berg,Joachim G.J.V. Aerts,A. F. M. Verbraak,Henk C. Hoogsteden,Jan M. Bogaard +5 more
TL;DR: In mechanically ventilated patients with and without COPD, a time constant can well be calculated from the expiratory flow-volume curve for the last 75% of tidal volume, gives a good estimation of respiratory mechanics, and is easy to obtain at the bedside.
Journal ArticleDOI
Immunoglobulin-like transcript 3 is expressed by myeloid-derived suppressor cells and correlates with survival in patients with non-small cell lung cancer
Pauline L. de Goeje,Koen Bezemer,Marlies E. Heuvers,Anne-Marie C. Dingemans,Harry J.M. Groen,Egbert F. Smit,Henk C. Hoogsteden,Rudi W. Hendriks,Joachim G.J.V. Aerts,Joost P.J.J. Hegmans +9 more
TL;DR: Interestingly, in line with the immunosuppressive function of ILT3 on dendritic cells, patients with an increased proportion of PMN-MDSCs and an increased fraction of theILT3high subset had a shorter median survival than patients with elevated PMN -MDSC and a smaller ILT2high fraction.
Journal ArticleDOI
Home Monitoring in Patients with Idiopathic Pulmonary Fibrosis: A Randomized Controlled Trial
Catharina C. Moor,Rémy L M Mostard,Jan C. Grutters,Paul Bresser,Joachim G.J.V. Aerts,Niels H. Chavannes,Marlies S. Wijsenbeek +6 more
TL;DR: The results of this first-ever eHealth RCT in IPF showed that a comprehensive home monitoring program did not improve overall HRQOL measured with K-BILD, but tended to improve psychological wellbeing.
Journal ArticleDOI
Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes.
Stephen C. Kanick,Cor van der Leest,Joachim G.J.V. Aerts,Henk C. Hoogsteden,Slávka Kaščáková,Henricus J. C. M. Sterenborg,Arjen Amelink +6 more
TL;DR: Model analysis of data from a clinical pilot study shows that the single-fiber reflectance measurement is capable of detecting differences in the physiology between normal and metastatic lymph nodes, and probe manipulation within the lymph node can perturb the in vivo environment.