Joakim S. Dahlin

TL;DR: Partition-based graph abstraction (PAGA) provides an interpretable graph-like map of the arising data manifold, based on estimating connectivity of manifold partitions, which preserves the global topology of data, allow analyzing data at different resolutions, and result in much higher computational efficiency of the typical exploratory data analysis workflow.

TL;DR: The evidences for cells and molecules that govern the migration of these cells in mice in vivo are described and only cell populations with enriched mast cell capability have been described in human.

TL;DR: In this article, the authors used single-cell RNA sequencing to identify a common basophil/mast cell bone marrow progenitor and characterized its molecular profile at the single cell level.

TL;DR: The method is demonstrated by inferring structure-rich cell maps with consistent topology across four hematopoietic datasets, confirm the reconstruction of lineage relations of adult planaria and the zebrafish embryo, benchmark computational performance on a neuronal dataset and detect a biological trajectory in one deep-learning processed image dataset.

TL;DR: It is proposed that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells.