Joan A. Keiser

TL;DR: These data are the first to show a direct effect of VEGF on SMCs, and suggest SMC-derived MMPs may be an additional source of proteases to digest vascular basement membrane, which is a crucial step in the initial stage of angiogenesis.

TL;DR: Screening of a compound library for inhibitors of the fibroblast growth factor and platelet-derived growth factor receptor tyrosine kinases led to the development of a novel series of ATP competitive pyrido[2,3-d]pyrimidine tyrosinesine kinase inhibitors, resulting in new analogs with improved potency, solubility, and bioavailability relative to the initial lead.

TL;DR: The results indicate that the pressor and adrenal effects observed with torcetrapib and related molecules are independent of CETP inhibition.

TL;DR: If it is determined that direct intramyocardial injection of angiogenic factors enhances collateral function in patients, this less invasive catheter-based system offers a similar gene delivery efficiency and, thus, may have clear advantages compared with the surgically-based transepicardial injection approach.

TL;DR: Results clearly show that all three thiophene systems have potent activity as antihypertensive agents and that 3 and 4 are more potent than 1 or 2 as alpha 1-antagonists in vivo.