Electromagnetic guidance for catheter-based transendocardial injection: a platform for intramyocardial angiogenesis therapy. Results in normal and ischemic porcine models.
Ran Kornowski,Martin B. Leon,Shmuel Fuchs,Yoram Vodovotz,M. A. Flynn,David A Gordon,Anthony Pierre,Imre Kovesdi,Joan A. Keiser,Stephen E. Epstein +9 more
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If it is determined that direct intramyocardial injection of angiogenic factors enhances collateral function in patients, this less invasive catheter-based system offers a similar gene delivery efficiency and, thus, may have clear advantages compared with the surgically-based transepicardial injection approach.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2000-03-15 and is currently open access. It has received 147 citations till now. The article focuses on the topics: Ultraviolet light.read more
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Phase 1/2 Placebo-Controlled, Double-Blind, Dose-Escalating Trial of Myocardial Vascular Endothelial Growth Factor 2 Gene Transfer by Catheter Delivery in Patients With Chronic Myocardial Ischemia
Douglas W. Losordo,Peter R. Vale,Robert C. Hendel,Charles E. Milliken,F. David Fortuin,Nancie Cummings,Richard A. Schatz,Takayuki Asahara,Jeffrey M. Isner,Richard E. Kuntz +9 more
TL;DR: Preliminary data provide preliminary data that support safety of phVEGF2 catheter-mediated myocardial gene transfer and strong positive trends for remaining end points suggest that a larger phase 2/3 trial is warranted.
Journal ArticleDOI
Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: A feasibility study
Shmuel Fuchs,Lowell F. Satler,Ran Kornowski,Petros Okubagzi,Giora Weisz,Richard Baffour,Ron Waksman,Neil J. Weissman,Manuel Cerqueira,Martin B. Leon,Stephen E. Epstein +10 more
TL;DR: Preliminary clinical data indicates feasibility of catheter-based transendocardial delivery of ABM to ischemic myocardium in patients with severe symptomatic chronic myocardial ischemia not amenable to conventional revascularization.
Journal ArticleDOI
Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia.
Peter R. Vale,Douglas W. Losordo,Charles E. Milliken,Maria C. McDonald,Laura M. Gravelin,Cynthia Curry,Darryl D. Esakof,Michael Maysky,James F. Symes,Jeffrey M. Isner +9 more
TL;DR: This pilot study to investigate the feasibility and safety of catheter-based myocardial GTx of naked plasmid DNA encoding vascular endothelial growth factor-2 (phVEGF-2) in patients with chronicMyocardial ischemia provides preliminary indications regarding the feasibility, safety, and potential efficacy of percutaneous myocardia GTx to human left ventricular myocardium.
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Angiogenesis Therapy Amidst the Hype, the Neglected Potential for Serious Side Effects
TL;DR: A discussion of potential complications of angiogenesis therapy based predominantly on knowledge of the underlying biological activities of 2 of the most potent angiogenic cytokines, vascular endothelial growth factor (VEGF) and fibroblast growthFactor (FGF).
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Therapeutic interventions for enhancing collateral development by administration of growth factors: basic principles, early results and potential hazards
TL;DR: There is ample experimental evidence justifying an optimistic outlook relating to the eventually being successful in enhancing collateral flow to ischemic tissue in a clinical setting, and an optimal angiogenesis intervention may require a 'multiple factor' strategy.
References
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Gene Therapy for Myocardial Angiogenesis : Initial Clinical Results With Direct Myocardial Injection of phVEGF165 as Sole Therapy for Myocardial Ischemia
Douglas W. Losordo,Peter R. Vale,James F. Symes,Cheryl H. Dunnington,Darryl D. Esakof,Michael Maysky,Alan B. Ashare,Kishor G. Lathi,Jeffrey M. Isner +8 more
TL;DR: This initial experience with naked gene transfer as sole therapy for myocardial ischemia suggests that directMyocardial injection of naked plasmid DNA, via a minimally invasive chest wall incision, is safe and may lead to reduced symptoms and improved myocardian perfusion in selected patients with chronic myocardia.
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A Novel Method for Nonfluoroscopic Catheter-Based Electroanatomical Mapping of the Heart In Vitro and In Vivo Accuracy Results
TL;DR: The main shortcomings of conventional mapping-namely, prolonged x-ray exposure, low spatial resolution, and the inability to accurately navigate to a predefined site-can all be overcome with this new method.
Journal ArticleDOI
Angiogenesis Gene Therapy Phase I Assessment of Direct Intramyocardial Administration of an Adenovirus Vector Expressing VEGF121 cDNA to Individuals With Clinically Significant Severe Coronary Artery Disease
Todd K. Rosengart,Leonard Y. Lee,Shailen R. Patel,Timothy A. Sanborn,Manish Parikh,Geoffrey Bergman,Rory Hachamovitch,Massimiliano Szulc,Paul Kligfield,Peter M. Okin,Rebecca T. Hahn,Richard B. Devereux,Martin R. Post,Neil R. Hackett,Taliba Foster,Tina M. Grasso,Martin Lesser,O. Wayne Isom,Ronald G. Crystal +18 more
TL;DR: The data are consistent with the concept that direct myocardial administration of Ad(GV)VEGF121.10 to individuals with clinically significant coronary artery disease appears to be well tolerated, and initiation of phase II evaluation of this therapy is warranted.
Journal ArticleDOI
Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.
Shmuel Banai,Michael T. Jaklitsch,Matie Shou,Daisy F. Lazarous,Mickey Scheinowitz,S. Biro,S E Epstein,Ellis F. Unger +7 more
TL;DR: It is concluded that intracoronary VEGF enhances the development of small coronary arteries supplying ischemic myocardium, resulting in marked augmentation of maximal collateral blood flow delivery and suggests a new therapeutic approach for the treatment of myocardial ischemia.
Journal ArticleDOI
Induction of Neoangiogenesis in Ischemic Myocardium by Human Growth Factors First Clinical Results of a New Treatment of Coronary Heart Disease
TL;DR: The use of FGF-I for myocardial revascularization is in principle a new concept and that it may be particularly suitable for patients with additional peripheral stenoses that cannot be revascularized surgically.
Related Papers (5)
Angiogenesis Gene Therapy Phase I Assessment of Direct Intramyocardial Administration of an Adenovirus Vector Expressing VEGF121 cDNA to Individuals With Clinically Significant Severe Coronary Artery Disease
Todd K. Rosengart,Leonard Y. Lee,Shailen R. Patel,Timothy A. Sanborn,Manish Parikh,Geoffrey Bergman,Rory Hachamovitch,Massimiliano Szulc,Paul Kligfield,Peter M. Okin,Rebecca T. Hahn,Richard B. Devereux,Martin R. Post,Neil R. Hackett,Taliba Foster,Tina M. Grasso,Martin Lesser,O. Wayne Isom,Ronald G. Crystal +18 more