J
Joan S. Brugge
Researcher at Harvard University
Publications - 302
Citations - 51153
Joan S. Brugge is an academic researcher from Harvard University. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & Phosphorylation. The author has an hindex of 115, co-authored 286 publications receiving 47965 citations. Previous affiliations of Joan S. Brugge include Howard Hughes Medical Institute & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Integrins and signal transduction pathways: the road taken
Edwin A. Clark,Joan S. Brugge +1 more
TL;DR: Recent advances in understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors are focused on.
Journal ArticleDOI
Cellular functions regulated by src family kinases
Sheila M. Thomas,Joan S. Brugge +1 more
TL;DR: This chapter reviews the evidence implicating Src family kinases in specific receptor pathways and describes the mechanisms leading to their activation, the targets that interact with these kinases, and the biological events that they regulate.
Journal ArticleDOI
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
TL;DR: A collection of protocols to culture MCF-10A cells, to establish stable pools expressing a gene of interest via retroviral infection, as well as to grow and analyzeMCF- 10A cells in three-dimensional basement membrane culture are provided.
Journal ArticleDOI
Modelling glandular epithelial cancers in three-dimensional cultures.
Jayanta Debnath,Joan S. Brugge +1 more
TL;DR: The important features of epithelial structures grown in 3D basement membrane cultures, and how such models have been used to investigate the mechanisms associated with tumour initiation and progression are reviewed.
Journal ArticleDOI
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.
M. Rozakis-Adcock,J McGlade,Geraldine Mbamalu,Giuliana Pelicci,Roger J. Daly,W. Li,A. Batzer,Sheila M. Thomas,Joan S. Brugge,Pier Giuseppe Pelicci,Joseph Schlessinger,Tony Pawson,Tony Pawson +12 more
TL;DR: The results suggest that She tyrosine phosphorylation can couple tyosine kinases to Grb2/Sem-5, through formation of a Shc-Grb2-Sem- 5 complex, and thereby regulate the mammalian Ras signalling pathway.