J
Joan S. Brugge
Researcher at Harvard University
Publications - 302
Citations - 51153
Joan S. Brugge is an academic researcher from Harvard University. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & Phosphorylation. The author has an hindex of 115, co-authored 286 publications receiving 47965 citations. Previous affiliations of Joan S. Brugge include Howard Hughes Medical Institute & Massachusetts Institute of Technology.
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Journal ArticleDOI
Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W. Locasale,Jason W. Locasale,Alexandra R. Grassian,Rameen Beroukhim,Matthew Meyerson,Gerhard Wagner,John M. Asara,John M. Asara,Joan S. Brugge,Matthew G. Vander Heiden,Lewis C. Cantley,Lewis C. Cantley +11 more
TL;DR: This work uses an integrated, quantitative metabolomics approach combining NMR experiments with heavy isotope labeling and targeted mass-spectrometry to demonstrate that altered metabolic flux stemming from glucose metabolism can be selected for in the development of cancer and contribute cell transformation.
Journal ArticleDOI
Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics
Joyce F. Liu,Sangeetha Palakurthi,Qing Zeng,Shan Zhou,Elena Ivanova,Wei Huang,Ioannis K. Zervantonakis,Laura M. Selfors,Yiping Shen,Colin C. Pritchard,Mei Zheng,Vilmos Adleff,Eniko Papp,Huiying Piao,Marian Novak,Susan Fotheringham,Gerburg M. Wulf,Jessie M. English,Paul Kirschmeier,Victor E. Velculescu,Cloud P. Paweletz,Gordon B. Mills,David M. Livingston,Joan S. Brugge,Ursula A. Matulonis,Ronny Drapkin +25 more
TL;DR: A collection of 14 clinically annotated and molecularly characterized luciferized ovarian PDX models in which orthotopic tumor burden in the intraperitoneal space can be followed by standard and reproducible methods is described.
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3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis.
Nobuaki Takahashi,Nobuaki Takahashi,Patricia S. Cho,Patricia S. Cho,Laura M. Selfors,Laura M. Selfors,Hendrik J. Kuiken,Hendrik J. Kuiken,Roma Kaul,Roma Kaul,Takuro Fujiwara,Isaac S. Harris,Isaac S. Harris,Tian Zhang,Steven P. Gygi,Joan S. Brugge,Joan S. Brugge +16 more
TL;DR: The results illustrate the value of spheroid culture in revealing environmental or spatial differential dependencies onNRF2 and reveal exploitable vulnerabilities of NRF2-hyperactivated tumors.
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Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase.
TL;DR: Phosphorylation of the inactive form of Src on Tyr527 occurred to a similar extent in cells lacking endogenous Src as it did in cells expressing Src, suggesting negative control of SRC kinase activity is mediated by another cellular protein tyrosine kinase.
Journal ArticleDOI
Activity of the multikinase inhibitor dasatinib against ovarian cancer cells
Gottfried E. Konecny,Gottfried E. Konecny,Ruth Glas,Judy Dering,Kanthinh Manivong,Jingwei Qi,Richard S. Finn,Guorong Yang,Hong Kl,C Ginther,Boris Winterhoff,Gao G,Joan S. Brugge,Dennis J. Slamon +13 more
TL;DR: These data provide a clear biological rationale to test dasatinib as a single agent or in combination with chemotherapy in patients with ovarian cancer, and suggest that cell lines with high expression of Yes, Lyn, Eph2A, caveolin-1 and 2, moesin, annexin-1, and uPA were particularly sensitive to d asatinib.