J
Joan S. Brugge
Researcher at Harvard University
Publications - 302
Citations - 51153
Joan S. Brugge is an academic researcher from Harvard University. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & Phosphorylation. The author has an hindex of 115, co-authored 286 publications receiving 47965 citations. Previous affiliations of Joan S. Brugge include Howard Hughes Medical Institute & Massachusetts Institute of Technology.
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Journal ArticleDOI
The myosin-II-responsive focal adhesion proteome: a tour de force?
TL;DR: A mass spectrometry approach reveals changes to the focal adhesion proteome on myosin inhibition, providing a valuable resource for the cell adhesion field.
Posted ContentDOI
Aging-associated alterations in the mammary gland revealed by single-cell RNA sequencing
Chunmei Li,Hana Kobayashi Shapiro,Christina Tsiobikas,Laura M. Selfors,Hanrong Chen,Hanrong Chen,Gray Gk,Yaara Oren,Yaara Oren,Luca Pinello,Luca Pinello,Aviv Regev,Joan S. Brugge +12 more
TL;DR: High-throughput single-cell RNA-sequencing profiling of mammary tissues from young and old nulliparous mice identified altered proportions and distinct gene expression patterns in numerous cell populations as a consequence of the aging process, independent of parity and lactation.
Journal ArticleDOI
United They Stand, Divided They Fall.
Isaac S. Harris,Joan S. Brugge +1 more
TL;DR: This issue highlights one adaptive mechanism to overcome these stresses that involves cell clustering, which induces a hypoxic environment and metabolic rewiring to buffer oxidative stress.
Journal ArticleDOI
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
Ashish Noronha,Nishanth Belugali Nataraj,Joo Sang Lee,Benny Zhitomirsky,Yaara Oren,Sara K. Oster,Moshit Lindzen,Saptaparna Mukherjee,Rainer Will,Soma Ghosh,Arturo Simoni-Nieves,Aakanksha Pathak Sitansu Kumar Verma,Rishita Chatterjee,Simone Borgoni,Welles Robinson,Sanju Sinha,Alexander Brandis,Daniel Lucas Kerr,Wei Wu,Aruna Ramanan Sekar,Suvendu Giri,Young Chul Chung,Diana Drago-Garcia,Brian P. Danysh,Mattia Lauriola,Michelangelo Fiorentino,Andrea Ardizzoni,Moshe Oren,Collin M. Blakely,Jideofor Ezike,Stefan Wiemann,Laxmi Parida,Trever G. Bivona,Rami I. Aqeilan,Joan S. Brugge,Aviv Regev,Gad Getz,Eytan Ruppin,Yosef Yarden +38 more
TL;DR: Treatment of lung cancer with EGFR inhibitors with AXL overexpression cured patient-derived xenografts and uncovered another hypermutator, AXL-driven activation of MYC and increased purine synthesis that is unbalanced by pyrimidines.
Journal Article
Phenotypic and genetic alterations in pre-cancerous cells in the colon.
TL;DR: Polyps and dysplastic lesions in ulcerative colitis have phenotypic changes and genetic changes which are characteristic of invasive cancers, and may be a late stage in the genetic evolution of colon cancer.