Joan S. Brugge

TL;DR: It is found that Bcl-xL overexpression in mouse mammary epithelial cells does not induce primary tumor formation or enhance MEK-induced tumorigenesis within the mammary gland environment, however, it strongly enhances metastatic potential.

TL;DR: The transforming activity of FGFR1 in mammary epithelial cells is shown and RSK is identified as a critical component ofFGFR1 signaling in lobular carcinomas, thus implicating RSK as a candidate therapeutic target in FG FR1-expressing tumors.

TL;DR: Clustering of the Syk chimera was found to be sufficient to stimulate early and late events normally induced by clustering of Fc epsilon RI, which strongly suggest that Syk is an early and critical mediator of multiple signaling pathways that emanate from the Fc EpsilonRI receptor and give rise to the allergic response.

TL;DR: It is demonstrated that a phosphoserine-containing form ofpp50 is present in uninfected chicken cells and that on transformation by RSV, a second form of pp50, detectable by two-dimensional analysis of 32P-labelled proteins, contains phosphotyrosine as well as phosphoserines.

TL;DR: In this paper, an optimized, highly versatile protocol for long-term culture of organoids derived from either normal human breast tissues or breast cancer (BC) tissues, as well as culturing conditions for a panel of 45 biobanked samples, including BC organoids covering all major disease subtypes (triple negative, estrogen receptor-positive/progesterone receptor)-positive and human epidermal growth receptor 2-positive).