J
Joan S. Brugge
Researcher at Harvard University
Publications - 302
Citations - 51153
Joan S. Brugge is an academic researcher from Harvard University. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & Phosphorylation. The author has an hindex of 115, co-authored 286 publications receiving 47965 citations. Previous affiliations of Joan S. Brugge include Howard Hughes Medical Institute & Massachusetts Institute of Technology.
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Journal ArticleDOI
The role of SV40 gene A in the alteration of microfilaments in transformed cells
TL;DR: Results indicate an association between the expression of a virus-specified function important to the maintenance of the transformed phenotype and the appearance of altered microfilament patterns in cultured animal cells.
Journal ArticleDOI
Unregulated ARF6 Activation in Epithelial Cysts Generates Hyperactive Signaling Endosomes and Disrupts Morphogenesis
Jogender S. Tushir,James W. Clancy,Andrew Warren,Carolyn N. Wrobel,Joan S. Brugge,Crislyn D'Souza-Schorey +5 more
TL;DR: This study shows that constitutive ARF6 activation during epithelial cyst morphogenesis promotes the formation of signaling endosomes that serve as platforms for hyperactive receptor signaling and leads to the generation of tumorigenic glandular phenotypes.
Proceedings ArticleDOI
Abstract S1-02: Final analysis of a phase II 3-arm randomized trial of neoadjuvant trastuzumab or lapatinib or the combination of trastuzumab and lapatinib, followed by six cycles of docetaxel and carboplatin with trastuzumab and/or lapatinib in patients with HER2+ breast cancer (TRIO-US B07)
S Hurvitz,JM Miller,R Dichmann,Alejandra T. Perez,Ravindranath Patel,LM Zehngebot,H. Allen,Linda D. Bosserman,B DiCarlo,A Kennedy,Armando E. Giuliano,CJ Calfa,David Molthrop,Aruna Mani,Judy Dering,H-J Wang,Brad Adams,Diego Martinez,H-w Chen,Jason J. Zoeller,Joan S. Brugge,DJ Slamon +21 more
TL;DR: Slamon et al. as discussed by the authors evaluated the clinical and molecular effects of neoadjuvant TC plus lapatinib (Ty) and/or Ty (8 mg/kg iv), followed by 6 cycles of q3-wkly TC (T: 75 mg/m2, C: AUC 5 or 6).
Journal ArticleDOI
Virus-specific RNA species present in the cytoplasm of Rous sarcoma virus-infected chicken cells.
TL;DR: Two major species of poly (A) -containing viral RNA sedimenting at 35 and 21 S were detected in wt and td virus-infected cells, suggesting that each RNA species serves as messenger in vivo.
Journal ArticleDOI
YB-1 translational control of epithelial-mesenchyme transition.
Ghassan Mouneimne,Joan S. Brugge +1 more
TL;DR: It is demonstrated that YB-1 regulates epithelial-mesenchyme transition (EMT) by inducing cap-independent translation of mRNAs encoding EMT-promoting factors and suppressing cap-dependenttranslation of m RNAs encoding growth-promote factors.