J
Joao A.R. Assad
Researcher at St Lukes Episcopal Hospital
Publications - 14
Citations - 2921
Joao A.R. Assad is an academic researcher from St Lukes Episcopal Hospital. The author has contributed to research in topics: Heart failure & Bone marrow. The author has an hindex of 7, co-authored 14 publications receiving 2876 citations.
Papers
More filters
Journal ArticleDOI
Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria Isabel D. Rossi,Antonio Carlos Carvalho,Hélio S. Dutra,Hans J.F. Dohmann,Guilherme V. Silva,Luciano Belem,Ricardo Vivacqua,Fernando Oswaldo Dias Rangel,Roberto Esporcatte,Yong-Jian Geng,William K. Vaughn,Joao A.R. Assad,Evandro Tinoco Mesquita,James T. Willerson +19 more
TL;DR: The present study demonstrates the relative safety of intramyocardial injections of bone marrow–derived stem cells in humans with severe heart failure and the potential for improving myocardial blood flow with associated enhancement of regional and global left ventricular function.
Journal ArticleDOI
Mesenchymal Stem Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart Function in a Canine Chronic Ischemia Model
Guilherme V. Silva,Silvio H. Litovsky,Joao A.R. Assad,Andre L.S. Sousa,Bradley J. Martin,Deborah Vela,Stephanie Coulter,Jing Lin,Judy Ober,William K. Vaughn,Rodrigo Branco,Edie M. Oliveira,Rumin He,Yong-Jian Geng,James T. Willerson,Emerson C. Perin +15 more
TL;DR: In a canine chronic ischemia model, MSCs differentiated into smooth muscle cells and endothelial cells, resulting in increased vascularity and improved cardiac function in the treated group.
Journal ArticleDOI
Improved Exercise Capacity and Ischemia 6 and 12 Months After Transendocardial Injection of Autologous Bone Marrow Mononuclear Cells for Ischemic Cardiomyopathy
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Guilherme V. Silva,Claudio Tinoco Mesquita,Luciano Belem,William K. Vaughn,Fernando Oswaldo Dias Rangel,Joao A.R. Assad,Antonio Carlos Carvalho,Rodrigo Branco,Maria Isabel D. Rossi,Hans J.F. Dohmann,James T. Willerson +15 more
TL;DR: The 6- and 12-month follow-up data suggest that transendocardial injection of ABMMNCs in patients with end-stage ischemic heart disease may produce a durable therapeutic effect and improve myocardial perfusion and exercise capacity.
Journal ArticleDOI
Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction.
Emerson C. Perin,Guilherme V. Silva,Joao A.R. Assad,Deborah Vela,Deborah Vela,L. Maximilian Buja,L. Maximilian Buja,Andre L.S. Sousa,Silvio H. Litovsky,Jing Lin,William K. Vaughn,Stephanie Coulter,Marlos R. Fernandes,Marlos R. Fernandes,James T. Willerson,James T. Willerson +15 more
TL;DR: In the comparison of transendocardial (TE) electromechanical-guided delivery of bone marrow mesenchymal stem cells (MSCs) after acute myocardial infarction, the TE group showed higher cell retention with an increased vascularity and greater functional improvement than did the IC group.
Journal ArticleDOI
Transendocardial Autologous Bone Marrow Mononuclear Cell Injection in Ischemic Heart Failure Postmortem Anatomicopathologic and Immunohistochemical Findings
Hans F. Dohmann,Emerson C. Perin,Christina Maeda Takiya,Guilherme V. Silva,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria-Isabel D. Rossi,Bernardo Miguel de Oliveira Pascarelli,Isabella Mariana de Assis,Hélio S. Dutra,Joao A.R. Assad,Rodrigo V. Castello-Branco,Cantidio Drummond,Hans J.F. Dohmann,James T. Willerson,Radovan Borojevic +16 more
TL;DR: Eleven months after treatment, morphological and immunocytochemical analysis of the sites of ABMM cell injection showed no abnormal cell growth or tissue lesions and suggested that an active process of angiogenesis was present in both the fibrotic cicatricial tissue and the adjacent cardiac muscle.