João T. Barata

TL;DR: LT expression by T‐ALL cells activates LTβR signalling in thymic stromal cells, thus promoting leukaemogenesis, and inactivation of Ltbr results in a significant delay in TEL‐JAK2‐induced leukaemia onset.

TL;DR: The results indicate that availability of BAFF determines BAFF-R and TACI expression on B cells, and that BAff-R expression is controlled by BAFF binding.

TL;DR: The work in this article was supported by the MRC under Programme Codes U117573801 and MR/P011225/1, to and by the consolidator grant ERC CoG-648455 from the European Research Council, under the European Union’s Horizon 2020 research and innovation programme, and the FAPESP/20015/2014 grant from Fundacao para a Ciencia e a Tecnologia (FCT) (J.T.B.).

TL;DR: Recent findings that shed light into the intricacies of TAL1 (epi)genetic regulation and the transcription network orchestrated by this major T-cell oncogene are emphasized.

TL;DR: It is shown that inhibition of CK2 induces apoptosis of CLL cells, whereas it does not significantly impact normal lymphocytes, demonstrating the selectivity of the CK2 inhibitors toward leukemia cells.