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Nádia C. Correia
Researcher at German Cancer Research Center
Publications - 11
Citations - 586
Nádia C. Correia is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: TAL1 & Stem cell. The author has an hindex of 7, co-authored 9 publications receiving 494 citations. Previous affiliations of Nádia C. Correia include Instituto de Medicina Molecular & University of Lisbon.
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Journal ArticleDOI
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Priscila Pini Zenatti,Daniel Dias Ribeiro,Wenqing Li,Linda Zuurbier,Milene Costa da Silva,Maddalena Paganin,Julia Tritapoe,Julie A. Hixon,André B. Silveira,Bruno A. Cardoso,Leonor M. Sarmento,Nádia C. Correia,María L. Toribio,Joerg Kobarg,Martin A. Horstmann,Rob Pieters,Silvia Regina Brandalise,Adolfo A. Ferrando,Jules P.P. Meijerink,Scott K. Durum,J. Andrés Yunes,João T. Barata +21 more
TL;DR: The findings indicate that IL7R mutational activation is involved in human T-cell leukemogenesis, paving the way for therapeutic targeting of IL-7R–mediated signaling in T-ALL.
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The multiple layers of non-genetic regulation of PTEN tumour suppressor activity
TL;DR: The key to evaluating the real impact of PTEN as a 'quasi-insufficient' tumour suppressor must rely on the complete understanding ofPTEN's 'functional dose', incorporating the multiple layers of PT EN regulation in the cell that are ultimately compromised in a given cancer.
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MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia
TL;DR: The results suggest that miR-146b-5p is a functionally relevant microRNA gene in the context of T-ALL, whose negative regulation by TAL1 and possibly other oncogenes contributes to disease progression by modulating leukemia cell motility and disease aggressiveness.
Journal ArticleDOI
microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia
Nádia C. Correia,Alice Melão,Vanda Póvoa,Leonor M. Sarmento,Marta Gómez de Cedrón,Marcos Malumbres,Francisco J. Enguita,João T. Barata +7 more
TL;DR: The results show for the first time the existence of epigenetic regulation of TAL1 by specific miRNAs which may contribute, at least in part, to the ectopic expression of Tal1 in some T-ALL cases.
Journal ArticleDOI
Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia.
Nádia C. Correia,Kaat Durinck,Ana Paula Leite,Maté Ongenaert,Pieter Rondou,Franki Speleman,Francisco J. Enguita,João T. Barata +7 more
TL;DR: Novel TAL1 targets beyond protein-coding genes are identified: identification of Tal1-regulated microRNAs in T-cell acute lymphoblastic leukemia and the role of EMT and “cell reprograming” in the development of leukemia.