J
João T. Barata
Researcher at Instituto de Medicina Molecular
Publications - 99
Citations - 4619
João T. Barata is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Leukemia & T cell. The author has an hindex of 36, co-authored 86 publications receiving 3956 citations. Previous affiliations of João T. Barata include University of Lisbon & Harvard University.
Papers
More filters
Journal ArticleDOI
A unified nomenclature and amino acid numbering for human PTEN.
Rafael Pulido,Suzanne J. Baker,João T. Barata,Arkaitz Carracedo,Arkaitz Carracedo,Víctor J. Cid,Ian D. Chin-Sang,Vrushank Davé,Jeroen den Hertog,Peter N. Devreotes,Britta J. Eickholt,Charis Eng,Frank B. Furnari,Maria Magdalena Georgescu,Arne Gericke,Benjamin D. Hopkins,Xeujun Jiang,Seung-Rock Lee,Mathias Lösche,Prerna Malaney,Xavier Matias-Guiu,María Molina,Pier Paolo Pandolfi,Ramon Parsons,Paolo Pinton,Carmen Rivas,Rafael Malagoli Rocha,Manuel S. Rodriguez,Alonzo H. Ross,Manuel Serrano,Vuk Stambolic,Bangyan L. Stiles,Akira Suzuki,Seong-Seng Tan,Nicholas K. Tonks,Lloyd C. Trotman,Nicolas Wolff,Rudiger Woscholski,Hong Wu,Nick R. Leslie +39 more
TL;DR: A unifying nomenclature and amino acid numbering for this previously uncharacterized form of PTEN has been proposed, that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site.
Journal Article
Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia
João T. Barata,Thomas D. Keenan,Ana Maria Silva,Lee M. Nadler,Vassiliki A. Boussiotis,Angelo A. Cardoso +5 more
TL;DR: The hypothesis that IL-7 may function as a critical regulator of T-ALL and that its activity may be potentiated by other Zc-cytokines is supported and synergistic effects may occur in vivo.
Journal ArticleDOI
Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells
Daniel V. Correia,Francisco d'Orey,Francisco d'Orey,Bruno A. Cardoso,Telma Lança,Telma Lança,Ana Rita Grosso,Ana deBarros,Ana deBarros,Leila R. Martins,João T. Barata,Bruno Silva-Santos,Bruno Silva-Santos +12 more
TL;DR: The most potent natural phosphoantigen yet identified, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), produced by Eubacteria and Protozoa is studied and its γδ T-cell activation and anti-tumor properties strongly support the usage of this microbial antigen in novel cancer clinical trials.
Journal ArticleDOI
STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells
Daniel Dias Ribeiro,Alice Melão,Ruben van Boxtel,Cristina Santos,Ana Elisa Bauer de Camargo Silva,Milene Costa da Silva,Bruno A. Cardoso,Paul J. Coffer,João T. Barata +8 more
TL;DR: It is demonstrated that strategies involving the use of PIM kinase small-molecule inhibitors may have therapeutic potential against a majority of leukemias that rely on IL-7 receptor (IL-7R) signaling.
Journal ArticleDOI
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
João T. Barata,Vassiliki A. Boussiotis,José Andrés Yunes,Adolfo A. Ferrando,Lisa A. Moreau,J. Pedro Veiga,Stephen E. Sallan,A. Thomas Look,Lee M. Nadler,Angelo A. Cardoso +9 more
TL;DR: A human interleukin-7 (IL-7)-dependent T-ALL cell line is established that maintains several biologic and signaling properties of its parental leukemia cells, and specific blockade of JAK3 by its inhibitor WHI-P131 abrogates the IL-7-mediated proliferation and survival of TAIL7 cells, suggesting that activation of Jak3 is critical for IL- 7 responsiveness by these cells.