TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
Jana Hartmann,Elena Dragicevic,Helmuth Adelsberger,Horst A. Henning,Martin Sumser,Joel Abramowitz,Robert Blum,Alexander Dietrich,Marc Freichel,Veit Flockerzi,Lutz Birnbaumer,Arthur Konnerth +11 more
TLDR
Taken together, the results establish TRPC3 as a new type of postsynaptic channel that mediates mGluR-dependent synaptic transmission in cerebellar Purkinje cells and is crucial for motor coordination.About:
This article is published in Neuron.The article was published on 2008-08-14 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Synaptic signaling & Synaptic augmentation.read more
Citations
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Imaging Calcium in Neurons
TL;DR: This Primer briefly reviews the general mechanisms of neuronal calcium signaling, and introduces the calcium imaging devices, including confocal and two-photon microscopy as well as miniaturized devices used in freely moving animals.
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International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
TL;DR: Recent progress on the physiology, pharmacology and pathophysiological function of mammalian TRP channels is reviewed to indicate that these channels have broad function in physiology.
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Transient receptor potential channels as therapeutic targets
TL;DR: This Review focuses on recent developments in the TRP channel-related field, and highlights potential opportunities for therapeutic intervention.
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Multiple Functions of Endocannabinoid Signaling in the Brain
István Katona,Tamás F. Freund +1 more
TL;DR: This work summarizes unexpected advances in the molecular complexity of biogenesis and inactivation of the two endocannabinoids, anandamide and 2-arachidonoylglycerol, and shows how new metabolic routes are integrated into well-known intracellular signaling pathways.
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Distributed synergistic plasticity and cerebellar learning
TL;DR: It is proposed that the different forms of plasticity in the granular layer and the molecular layer operate synergistically in a temporally and spatially distributed manner, so as to ultimately create optimal output for behaviour.
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