J
Joel B. Kirkpatrick
Researcher at Baylor College of Medicine
Publications - 21
Citations - 1867
Joel B. Kirkpatrick is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Microglia & Subarachnoid hemorrhage. The author has an hindex of 13, co-authored 21 publications receiving 1822 citations. Previous affiliations of Joel B. Kirkpatrick include Houston Methodist Hospital.
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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.
Yu Min Kuo,Mark R. Emmerling,Carmen Vigo-Pelfrey,Timothy C. Kasunic,Joel B. Kirkpatrick,Geoffrey Murdoch,Melvyn J. Ball,Alex E. Roher +7 more
TL;DR: It is likely that the water-soluble Aβ peptides the authors quantified are precursors to its insoluble, filamentous form, and reducing the levels of soluble Aβ in AD brains could have profound effects on AD pathophysiology.
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Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia
Dana Giulian,Lanny J. Haverkamp,Jiahan Yu,William Karshin,Donald Tom,Jun Li,Joel B. Kirkpatrick,Yu Min Kuo,Alex E. Roher +8 more
TL;DR: Findings suggested that specific portions of human Aβ were necessary for microglia–plaque interactions that occur in AD, which might prevent the immune-driven injury to neurons.
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Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain.
Dana Giulian,Lanny J. Haverkamp,Jun Li,William Karshin,Jenny Yu,Donald Tom,Xia Li,Joel B. Kirkpatrick +7 more
TL;DR: High concentrations of the neurotoxin are in those brain structures most burdened by reactive microglia, suggesting that plaque-activated cells contribute to the neuronal damage and impaired cognition seen in patients with Alzheimer's dementia.
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The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease *
Dana Giulian,Lanny J. Haverkamp,Jiahan Yu,William Karshin,Donald Tom,Jun Li,Anna Kazanskaia,Joel B. Kirkpatrick,Joel B. Kirkpatrick,Alex E. Roher +9 more
TL;DR: In vivo experiments confirmed that the H HQK peptide reduces rat brain inflammation elicited after infusion of Aβ peptides or implantation of native plaque fragments, suggesting membrane-associated heparan sulfate mediated plaque-microglia interactions through the HHQK domain.
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Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte
TL;DR: Application of cell surface criteria described here will allow study of distinct populations of mononuclear phagocytes associated with neurologic disorders, including brain-derived microglia and other classes of immune cells.