J
Joel LeMaoult
Researcher at University of Paris
Publications - 90
Citations - 6527
Joel LeMaoult is an academic researcher from University of Paris. The author has contributed to research in topics: HLA-G & Immune system. The author has an hindex of 42, co-authored 86 publications receiving 5901 citations. Previous affiliations of Joel LeMaoult include Cornell University & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
HLA-G: from biology to clinical benefits
TL;DR: The clinical implications of HLA-G as a tolerogenic molecule promoting uterine implantation of the embryo or acceptance of solid allografts while allowing the evasion of tumors or viruses from the immune response are reported.
Journal ArticleDOI
Beyond the increasing complexity of the immunomodulatory HLA-G molecule.
TL;DR: The case for considering HLA-G as clinically relevant in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies, is strengthened by what is considered here what are recent key basic findings on the immunomodulatory function of Hla-G.
Journal ArticleDOI
HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells
TL;DR: It is shown here that HLA-G1+ APCs are immunoinhibitory cells that inhibit the proliferation of CD4+ T cells, shed HLA -G1 molecules that might provide extra, non-antigen-specific, inhibitory or proapoptotic signals, and induce CD4- T cell anergy, or at least long-term unresponsiveness.
Journal ArticleDOI
Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense.
Ilhem Messaoudi,José A. Guevara Patiño,Ruben Dyall,Joel LeMaoult,Janko Nikolich-Zugich,Janko Nikolich-Zugich +5 more
TL;DR: Mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire is linked to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense.
Book ChapterDOI
HLA-G: An Immune Checkpoint Molecule.
Edgardo D. Carosella,Nathalie Rouas-Freiss,Diana Tronik-Le Roux,Philippe Moreau,Joel LeMaoult +4 more
TL;DR: This work focuses on transplantation and oncology because these pathological contexts have been studied the most and also because they best represent the two opposite sides of HLA-G: beneficial to be promoted, or deleterious to be blocked.