Johan Ankarklev

TL;DR: In this paper, spatial transcriptomics of liver tissue is used to delineate transcriptional differences in physical space, confirm lobular zonation along transcriptional gradients and suggest the presence of previously uncharacterized structures within liver tissue.

TL;DR: Surprisingly, the assemblage E and A isolates are more similar at the amino-acid level than the two human isolate are to each other, which strengthens the earlier data suggesting that humans are infected by two different species of Giardia.

TL;DR: This study demonstrates how comprehensive spatial transcriptomic technologies can be used to delineate extensive spatial gene expression patterns in the liver, indicating its future impact for studies of liver function, development and regeneration as well as its potential in pre-clinical and clinical pathology.

TL;DR: Allelic discrimination and gene or transcript localization by FISH not only provide insights into transcriptional regulation of genes such as the virulence associated var genes, but also suggest that this sensitive and precise approach could be used for further investigation of genome dynamics and gene regulation.

TL;DR: A novel and expanded MLST strategy with significantly improved sensitivity for molecular analyses of virulence types, zoonotic potential and source tracking for assemblage A Giardia.