J
Johan P. Turkenburg
Researcher at University of York
Publications - 126
Citations - 8279
Johan P. Turkenburg is an academic researcher from University of York. The author has contributed to research in topics: Hydrolase & Glycoside hydrolase. The author has an hindex of 41, co-authored 124 publications receiving 7492 citations. Previous affiliations of Johan P. Turkenburg include New York University & Newcastle University.
Papers
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Journal ArticleDOI
Purification, crystallization and preliminary X-ray diffraction analysis of the Trichoderma reesei hydrophobin HFBI
Sanna Askolin,Johan P. Turkenburg,Maija Tenkanen,Sinikka Uotila,Keith S. Wilson,Merja Penttilä,Kalevi Visuri +6 more
TL;DR: The growth of hydrophobin crystals suitable for X-ray crystallography is reported, and the HFBI from Trichoderma reesei was crystallized by vapour diffusion in hanging drops in 30% PEG 4000, 0.3 buffer containing 0.2 M ammonium acetate and CYMAL-5 detergent.
Journal ArticleDOI
I222 crystal form of despentapeptide (B26–B30) insulin provides new insights into the properties of monomeric insulin
Jean L. Whittingham,Zhang Youshang,Lenka Zakova,Eleanor J. Dodson,Johan P. Turkenburg,Jens Brange,Guy Dodson +6 more
TL;DR: DPI, an active modified insulin, has been crystallized in the presence of 20% acetic acid pH 2.8 A and two crystallographically independent molecules within the dimer were essentially identical and were similar in conformation to T-state insulin as seen in the T(6) insulin hexamer.
Patent
Crystal structure of a mutant of cathepsin S enzyme
TL;DR: In this article, the X-ray crystal structure of a cathepsin S mutant was used to construct a three-dimensional representation of the binding pocket of the mutant's binding pocket.
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Insulin Assembly: Its Modification by Protein Engineering and Ligand Binding
Eleanor J. Dodson,George Guy Dodson,Roderick E. Hubbard,Peter C. E. Moody,Johan P. Turkenburg,Jean L. Whittingham,B. Xiao,J. Brange,Niels C. Kaarsholm,H. Thogersen +9 more
TL;DR: In this article, X-ray analysis of insulin crystals has revealed the nature of the surfaces involved in its assembly to dimers and hexamers, and experiments to improve insulin absorption at the injection site have been based on constructing monomeric insulins by protein engineering.
Journal ArticleDOI
Mutant insulin crystal packing
Bing Xiao,Guy Dodson,Eleanor J. Dodson,J. Clarkson,Johan P. Turkenburg,U. Derewenda,Leo Brady,Jens Brange +7 more
TL;DR: In this paper, a comparative study between mutant and native insulins in different crystal forms and structural conformations has revealed certain differences among them in terms of crystal packing, which may facilitate internal interactions in mutants.