R
Roderick E. Hubbard
Researcher at University of York
Publications - 139
Citations - 16771
Roderick E. Hubbard is an academic researcher from University of York. The author has contributed to research in topics: Fragment-based lead discovery & Ligand (biochemistry). The author has an hindex of 51, co-authored 136 publications receiving 15588 citations. Previous affiliations of Roderick E. Hubbard include Hull York Medical School & John Radcliffe Hospital.
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Journal ArticleDOI
Molecular basis of agonism and antagonism in the oestrogen receptor.
Andrzej M. Brzozowski,Ashley C. W. Pike,Zbigniew Dauter,Roderick E. Hubbard,Tomas Bonn,Owe Engström,Lars Öhman,Geoffrey L. Greene,Jan-Åke Gustafsson,Mats Carlquist +9 more
TL;DR: The crystal structures of the LBD of ER in complex with the endogenous oestrogen, 17β-oestradiol, and the selective antagonist raloxifene provide a molecular basis for the distinctive pharmacophore of the ER and its catholic binding properties.
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Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport.
Stephen C. Hyde,Paul Emsley,Michael J. Hartshorn,Michael M. Mimmack,Uzi Gileadi,Stephen R. Pearce,Stephen R. Pearce,Maurice P. Gallagher,Maurice P. Gallagher,Deborah R. Gill,Roderick E. Hubbard,Christopher F. Higgins +11 more
TL;DR: A tertiary structure model of the ATP-binding cassettes characteristic of this class of transport system is presented, based on similarities between the predicted secondary structures of members of this family and the previously determined structure of adenylate kinase.
Journal ArticleDOI
Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist
Ashley C. W. Pike,Andrzej M. Brzozowski,Roderick E. Hubbard,Tomas Bonn,Ann Gerd Thorsell,Owe Engström,Jan Ljunggren,Jan-Åke Gustafsson,Mats Carlquist +8 more
TL;DR: The three‐dimensional structure of the oestrogen receptor beta isoform (ERβ) ligand‐binding domain (LBD) in the presence of the phyto‐oestrogen genistein and the antagonist raloxifene is reported.
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Twenty years on: the impact of fragments on drug discovery.
TL;DR: How to design fragment libraries, how to select screening techniques and how to make the most of information gleaned from them are discussed, and how concepts from FBDD have permeated and enhanced drug discovery efforts are shown.