J
Johann S. Braun
Researcher at Charité
Publications - 56
Citations - 4678
Johann S. Braun is an academic researcher from Charité. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 27, co-authored 52 publications receiving 4434 citations. Previous affiliations of Johann S. Braun include Humboldt University of Berlin & Humboldt State University.
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Journal ArticleDOI
Electron beam computed tomography in the evaluation of cardiac calcifications in chronic dialysis patients
Johann S. Braun,Johann S. Braun,Manfred Oldendorf,Manfred Oldendorf,Werner Moshage,Werner Moshage,Rudolf Heidler,Rudolf Heidler,Eberhard Zeitler,Eberhard Zeitler,Friedrich C. Luft,Friedrich C. Luft +11 more
TL;DR: The authors' data under-score the frequency and severity of coronary and valvular calcifications in dialysis patients, and illustrate the rapid progression of this calcification, drawing attention to hypertension as an important risk factor in this process.
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Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation.
Konstantin Prass,Christian Meisel,Conny Höflich,Johann S. Braun,E. Halle,Tilo Wolf,Karsten Ruscher,Ilya V. Victorov,Josef Priller,Ulrich Dirnagl,Hans-Dieter Volk,Andreas Meisel +11 more
TL;DR: It is suggested that a catecholamine-mediated defect in early lymphocyte activation is the key factor in the impaired antibacterial immune response after stroke.
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Stroke-Induced Immunodepression Experimental Evidence and Clinical Relevance
Ulrich Dirnagl,Juliane Klehmet,Johann S. Braun,Hendrik J. Harms,Christian Meisel,Tjalf Ziemssen,Konstantin Prass,Andreas Meisel +7 more
TL;DR: Clinical evidence is emerging demonstrating that stroke-induced immunodepression in humans not only exists, but has very similar features to those characterized in rodent experiments.
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Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis
Johann S. Braun,Jack Sublett,Dorette Freyer,Timothy J. Mitchell,John L. Cleveland,Elaine Tuomanen,Joerg R. Weber +6 more
TL;DR: Two bacterial toxins, pneumolysin and, to a lesser extent, H(2)O(2), induce apoptosis by translocation of AIF, suggesting new neuroprotective strategies for pneumococcal meningitis.
Journal ArticleDOI
Neuroprotection by a caspase inhibitor in acute bacterial meningitis.
Johann S. Braun,Rodger Novak,K H Herzog,S M Bodner,John L. Cleveland,John L. Cleveland,Elaine Tuomanen +6 more
TL;DR: It is demonstrated that the broad-spectrum caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl-ketone (z-VAD-fmk) prevented hippocampal neuronal cell death and white blood cell influx into the cerebrospinal fluid compartment in experimental pneumococcal meningitis.