Johanna Liebl

TL;DR: The results indicate that archazolid effectively decreases metastatic dissemination of breast tumors by impairing the trafficking and spatially restricted activation of EGFR and Rho-GTPase Rac1, which are pivotal for directed movement of cells.

TL;DR: It is shown that cyclin-dependent kinase 5 (Cdk5), an important modulator of neuronal processes, regulates endothelial cell migration and angiogenesis, suggesting Cdk5 as a novel target for antiangiogenic therapy.

TL;DR: Cdk5 is introduced as a novel drugable target for HCC treatment and the combination of Cdk5 inhibition and DNA damaging agents as a Novel therapeutic approach is suggested.

TL;DR: This study offers preclinical evidence of an important metabolic mechanism underlying the antitumor activity of inhibitors of the vacuolar-type ATPase (V-ATPase), a heteromultimeric proton pump, and links V- ATPase to cell-cycle progression and DNA synthesis in cancer cells.

TL;DR: Issues of pharmacological inhibition, the versatile roles, and the growing evidence for the functional importance of Cdk5 in non-neuronal tissues are discussed, including blood cells, tumor cells, epithelial cells, the vascular endothelium, testis, adipose and endocrine tissues.