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Johannes M. H. M. Reul

Researcher at University of Bristol

Publications -  172
Citations -  18929

Johannes M. H. M. Reul is an academic researcher from University of Bristol. The author has contributed to research in topics: Glucocorticoid receptor & Glucocorticoid. The author has an hindex of 74, co-authored 170 publications receiving 18211 citations. Previous affiliations of Johannes M. H. M. Reul include Utrecht University & National Scientific and Technical Research Council.

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Journal ArticleDOI

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

Johannes M. H. M. Reul, +1 more
- 01 Dec 1985 - 
TL;DR: It is concluded that CORT action via CR may be involved in a tonic (permissive) influence on brain function with the septohippocampal complex as a primary target.
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Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

Peter Timpl, +9 more
- 01 Jun 1998 - 
TL;DR: It is shown that in mice lacking Crhr1, the medulla of the adrenal gland is atrophied and stress-induced release of adrenocorticotropic hormone (ACTH) and corticosterone is reduced and the homozygous mutants exhibit increased exploratory activity and reduced anxiety-related behaviour under both basal conditions and following alcohol withdrawal.
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Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems

E.R. de Kloet, +1 more
- 01 Jan 1987 - 
TL;DR: Two types of corticosteroid receptors can be distinguished in rat brain and the CR has its predominant localization in neurons of the septo-hippocampal complex and has a ten-fold higher affinity for CORT than that of the GR, which mediates a tonic influence exerted with stringent specificity by CORT on hippocampus-associated functions.
Journal ArticleDOI

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.

Johannes M. H. M. Reul, +1 more
- 01 Feb 2002 - 
TL;DR: CRF, the urocortins and their receptors form an intricate network in the brain involved in the acute phase as well as the recovery phase of the stress response.
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Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

Marianne B. Müller, +11 more
- 14 Sep 2003 - 
TL;DR: The data clearly show that limbic Crhr1 modulates anxiety-related behavior and that this effect is independent of HPA system function, and provide evidence for a new role of limbicCrhr1 in neuroendocrine adaptation to stress.