M
Marieke A. D. van Zoelen
Researcher at University of Amsterdam
Publications - 30
Citations - 3190
Marieke A. D. van Zoelen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Inflammation & Sepsis. The author has an hindex of 22, co-authored 30 publications receiving 2880 citations. Previous affiliations of Marieke A. D. van Zoelen include University of Michigan.
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Journal ArticleDOI
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Thomas Vogl,Klaus Tenbrock,Stephan Ludwig,Nadja Leukert,Christina Ehrhardt,Marieke A. D. van Zoelen,Wolfgang Nacken,Dirk Foell,Tom van der Poll,Clemens Sorg,Johannes Roth +10 more
TL;DR: It is demonstrated that mice lacking Mrp8-Mrp14 complexes are protected from endotoxin-induced lethal shock and Escherichia coli–induced abdominal sepsis, indicating new inflammatory components that amplify phagocyte activation during sepsi upstream of TNFα–dependent effects.
Journal ArticleDOI
Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo
Marieke A. D. van Zoelen,Huan Yang,Sandrine Florquin,Joost C. M. Meijers,Shizuo Akira,Bernd Arnold,Peter P. Nawroth,Angelika Bierhaus,Kevin J. Tracey,Tom van der Poll +9 more
TL;DR: Data indicate that HMGB-1 induces release of cytokines, activation of coagulation, and neutrophil recruitment in vivo via a mechanism that at least in part depends on TLR-4 and RAGE.
Journal ArticleDOI
Induction of IRAK-M Is Associated with Lipopolysaccharide Tolerance in a Human Endotoxemia Model
Cornelis van 't Veer,Petra S. van den Pangaart,Marieke A. D. van Zoelen,Martijn D. de Kruif,Rakesh S. Birjmohun,E.S.G. Stroes,Alex F. de Vos,Tom van der Poll +7 more
TL;DR: Analysis of expression kinetics of MyD88short, IL-1R-associated kinase (IRAK)-1, IRAK-M, ST2, suppressor of cytokine signaling-1 and -3, SHIP-1, and MAP kinase phosphatase-1 expression indicated that the observed LPS tolerance was associated with decreased IRAK -1 and elevated IRAk-M expression in this human model.
Journal ArticleDOI
Proinflammatory S100A12 Can Activate Human Monocytes via Toll-like Receptor 4
Dirk Foell,Helmut Wittkowski,Christoph Kessel,Aloys Lüken,Toni Weinhage,Georg Varga,Thomas J. Vogl,Timo Wirth,Dorothee Viemann,Per Björk,Marieke A. D. van Zoelen,Faekah Gohar,Geetha Srikrishna,Matthias Kraft,Johannes Roth +14 more
TL;DR: Human S100A12 is an endogenous TLR4 ligand that induces monocyte activation, thereby acting as an amplifier of innate immunity during early inflammation and the development of sepsis.
Journal ArticleDOI
Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis
Ahmed Achouiti,Thomas Vogl,Constantin F. Urban,Marc Röhm,Tijmen J. Hommes,Marieke A. D. van Zoelen,Sandrine Florquin,Johannes Roth,Cornelis van 't Veer,Alex F. de Vos,Tom van der Poll +10 more
TL;DR: The role of MRP8/14 is identified as key player in protective innate immunity during Klebsiella pneumonia using an established model characterized by gradual growth of bacteria with subsequent dissemination.