J
Johannes Schmitt
Researcher at University of Zurich
Publications - 41
Citations - 1534
Johannes Schmitt is an academic researcher from University of Zurich. The author has contributed to research in topics: Bile acid & Calcitriol receptor. The author has an hindex of 20, co-authored 41 publications receiving 1327 citations. Previous affiliations of Johannes Schmitt include University of Würzburg.
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Journal ArticleDOI
Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid‐induced liver injury in superobese patients with nonalcoholic steatohepatitis
Lars P. Bechmann,Peri Kocabayoglu,Peri Kocabayoglu,Jan-Peter Sowa,Svenja Sydor,Jan Best,Martin Schlattjan,Anja Beilfuss,Johannes Schmitt,Rebekka A. Hannivoort,Rebekka A. Hannivoort,Alpaslan Kilicarslan,Alpaslan Kilicarslan,Christian Rust,Frieder Berr,Oliver Tschopp,Guido Gerken,Scott L. Friedman,Andreas Geier,Ali Canbay +19 more
TL;DR: BA synthesis and serum BA levels correlated with disease severity in NAFLD, while adiponectin is reversely correlated, and early treatment with FXR ligands and/or adiponECTin‐receptor agonists might prevent NASH.
Journal ArticleDOI
Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope
Johannes Schmitt,Ricardo Benavente,Didier Hodzic,Christer Höög,Colin L. Stewart,Manfred Alsheimer +5 more
TL;DR: This study indicates that the molecular mechanisms required for tethering meiotic telomeres and their dynamic movements during bouquet formation are conserved among eukaryotes.
Journal ArticleDOI
Mammalian sperm head formation involves different polarization of two novel LINC complexes.
TL;DR: The findings suggest that theses LINC complexes connect the differentiating spermatid nucleus to surrounding cytoskeletal structures to enable its well-directed shaping and elongation, which in turn is a critical parameter for male fertility.
Journal ArticleDOI
Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis.
Philip P. Becker,Monika Rau,Johannes Schmitt,Carolin Malsch,Christian Hammer,Heike Bantel,Beat Müllhaupt,Andreas Geier +7 more
TL;DR: Candidates for a combined model of miRNAs and CK18-Asp396 levels relevant as a promising expansion for diagnosis and in turn treatment of NASH are defined.
Journal ArticleDOI
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
Johannes Schmitt,Bo Kong,Bruno Stieger,Oliver Tschopp,Simon M. Schultze,Monika Rau,Achim Weber,Beat Müllhaupt,Grace L. Guo,Andreas Geier +9 more
TL;DR: Organ‐specific Fxr knockout mice were used to further investigate the influence of farnesoid X receptor FXR in lipogenesis and bile acids are involved in the regulation of triglyceride‐, cholesterol‐homoeostasis and fat absorption.