Journal ArticleDOI
Role of Glycosylation in Development
Reads0
Chats0
TLDR
A review of recent studies analyzing function of a variety of glycoconjugates, focusing on lessons learned from human disease and genetic studies in mice, Drosophila melanogaster, and Caenorhabditis elegans, suggests that O-fucose, O-mannose, N-glycans, mucin-type O-gly cans and proteoglycans are likely to play important roles in developmental processes.Abstract:
Researchers have long predicted that complex carbohydrates on cell surfaces would play important roles in developmental processes because of the observation that specific carbohydrate structures appear in specific spatial and temporal patterns throughout development. The astounding number and complexity of carbohydrate structures on cell surfaces added support to the concept that glycoconjugates would function in cellular communication during development. Although the structural complexity inherent in glycoconjugates has slowed advances in our understanding of their functions, the complete sequencing of the genomes of organisms classically used in developmental studies (e.g., mice, Drosophila melanogaster, and Caenorhabditis elegans) has led to demonstration of essential functions for a number of glycoconjugates in developmental processes. Here we present a review of recent studies analyzing function of a variety of glycoconjugates (O-fucose, O-mannose, N-glycans, mucin-type O-glycans, proteoglycans, glycosphingolipids), focusing on lessons learned from human disease and genetic studies in mice, D. melanogaster, and C. elegans.read more
Citations
More filters
Journal ArticleDOI
GLYCAM06: a generalizable biomolecular force field. Carbohydrates.
Karl N. Kirschner,Austin B. Yongye,Sarah M. Tschampel,Jorge Gonzalez-Outeiriño,Charlisa R. Daniels,B. Lachele Foley,Robert J. Woods +6 more
TL;DR: It is demonstrated that deriving dihedral parameters by fitting to QM data for internal rotational energy curves for representative small molecules generally leads to correct rotamer populations in molecular dynamics simulations, and that this approach removes the need for phase corrections in the dihedral terms.
Journal ArticleDOI
Biological Roles of Glycans
TL;DR: It is time for the diverse functional roles of glycans to be fully incorporated into the mainstream of biological sciences, as they are no different from other major macromolecular building blocks of life, simply more rapidly evolving and complex.
Journal ArticleDOI
Heparan sulphate proteoglycans fine-tune mammalian physiology
TL;DR: Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices, which affects metabolism, transport, information transfer, support and regulation in all organ systems.
Journal ArticleDOI
Vertebrate protein glycosylation: diversity, synthesis and function
TL;DR: Improvements in analytical methodologies for dissecting glycan structural diversity, along with recent developments in biochemical and genetic approaches for studying glycan biosynthesis and catabolism have provided a greater understanding of the biological contributions of these complex structures in vertebrates.
Journal ArticleDOI
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
TL;DR: Using a multicolor detection strategy, a spatiotemporal analysis of glycan expression and trafficking is performed and patterns that would be undetectable with conventional molecular imaging approaches are identified.
References
More filters
Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
Journal ArticleDOI
Assembly of asparagine-linked oligosaccharides.
TL;DR: The structure of ASPARAGINE-LINKed OLIGOSACCI-IARIDES and transfer-Oligosaccharide Structural Requirements, and Sequence of Processing and Specificity of Processing Enzymes are presented.
Book
Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
TL;DR: General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.
Journal ArticleDOI
Functions of Cell Surface Heparan Sulfate Proteoglycans
Merton Bernfield,Martin Götte,Pyong Woo Park,Ofer Reizes,Marilyn L. Fitzgerald,John Lincecum,Masahiro Zako +6 more
TL;DR: Current analyses of genetic defects in Drosophila melanogaster, mice, and humans confirm most of these activities in vivo and identify additional processes that involve cell surface heparan sulfate proteoglycans.
Journal ArticleDOI
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
Leif W. Ellisen,Jeffrey Bird,Daniel C. West,A. Lee Soreng,Thomas C. Reynolds,Stephen D. Smith,Jeffrey Sklar +6 more
TL;DR: It is shown that the locus on chromosome 9 contains a gene highly homologous to the Drosophila gene Notch, which may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms.