R
Rajan P. Nair
Researcher at University of Michigan
Publications - 117
Citations - 14052
Rajan P. Nair is an academic researcher from University of Michigan. The author has contributed to research in topics: Psoriasis & Genome-wide association study. The author has an hindex of 54, co-authored 109 publications receiving 12775 citations. Previous affiliations of Rajan P. Nair include University Health Network & Veterans Health Administration.
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Journal ArticleDOI
Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
Rajan P. Nair,Kristina Callis Duffin,Cynthia Helms,Jun Ding,Philip E. Stuart,David E. Goldgar,Johann E. Gudjonsson,Yun Li,Trilokraj Tejasvi,Bing Jian Feng,Andreas Ruether,Stefan Schreiber,Michael Weichenthal,Dafna D. Gladman,Proton Rahman,Steven J. Schrodi,Sampath Prahalad,Sampath Prahalad,Stephen L. Guthery,Stephen L. Guthery,Judith Fischer,Wilson Liao,Pui-Yan Kwok,Alan Menter,G. Mark Lathrop,Carol Wise,Ann B. Begovich,John J. Voorhees,James T. Elder,James T. Elder,Gerald G. Krueger,Anne M. Bowcock,Gonçalo R. Abecasis +32 more
TL;DR: The results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 × 10−8) and suggest priority targets for study in other auto-immune disorders.
Journal ArticleDOI
ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA.
John B. Lowe,Lloyd M. Stoolman,Rajan P. Nair,Robert D. Larsen,Terry L. Berhend,Rory M. Marks +5 more
TL;DR: It is demonstrated that transfection of a human fucosyltransferase cDNA into nonmyeloid cell lines confers ELAM-1--dependent endothelial adhesion, and it is proposed that specific alpha(1,3)fucOSyltransferases regulate cell adhesion to ELam-1 by modulating cell surface expression of one or more alpha(2,3).
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Sequence and Haplotype Analysis Supports HLA-C as the Psoriasis Susceptibility 1 Gene
Rajan P. Nair,Philip E. Stuart,Ioana Nistor,Ravi Hiremagalore,Nicholas V.C. Chia,Stefan Jenisch,Michael Weichenthal,Gonçalo R. Abecasis,Henry W. Lim,Enno Christophers,John J. Voorhees,James T. Elder,James T. Elder +12 more
TL;DR: Results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis.
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Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
Rafael de Cid,Eva Riveira-Muñoz,Patrick L.J.M. Zeeuwen,Jason Robarge,Wilson Liao,Emma N. Dannhauser,Emiliano Giardina,Philip E. Stuart,Rajan P. Nair,Cynthia Helms,Geòrgia Escaramís,Ester Ballana,Gemma Martin-Ezquerra,Martin den Heijer,Marijke Kamsteeg,Irma Joosten,Evan E. Eichler,Conxi Lázaro,Ramon M. Pujol,Lluís Armengol,Gonçalo R. Abecasis,James T. Elder,Giuseppe Novelli,John A.L. Armour,Pui-Yan Kwok,Anne M. Bowcock,Joost Schalkwijk,Xavier Estivill +27 more
TL;DR: LCE expression can be induced in normal epidermis by skin barrier disruption and is strongly expressed in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility.
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A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.
TL;DR: Results indicate that this cDNA is the product of the human Lewis blood group locus, provide genetic confirmation of the hypothesis that this enzyme can catalyze two distinct transglycosylation reactions, and outline an approach to the isolation of other sequences that determine expression of developmentally regulated oligosaccharide antigens.