J
John C. Wootton
Researcher at University of Leeds
Publications - 32
Citations - 1778
John C. Wootton is an academic researcher from University of Leeds. The author has contributed to research in topics: Glutamate dehydrogenase & Peptide sequence. The author has an hindex of 21, co-authored 32 publications receiving 1721 citations. Previous affiliations of John C. Wootton include University of Sheffield.
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Genetic and molecular analysis of a cluster of rpf genes involved in positive regulation of synthesis of extracellular enzymes and polysaccharide in Xanthomonas campestris pathovar campestris.
TL;DR: The results indicate that this region of the genome contains a cluster of genes, mutation in any of which results in failure of the enzymes and extracellular polysaccharide to be synthesized.
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Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases
TL;DR: Genome-wide association revealed that a single quantitative trait locus controls the dramatic difference in lethality between these strain types, revealing that a locus of polymorphic pseudokinases plays an important role in pathogenesis of toxoplasmosis in the mouse model.
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The Q-linker: a class of interdomain sequences found in bacterial multidomain regulatory proteins.
John C. Wootton,M.H. Drummond +1 more
TL;DR: Results suggest that the Q-linker serves a simple but essential role in tethering the structurally-distinct but interacting domains of the protein, potentially applicable as domain fusion junctions for engineered chimaeric multidomain proteins expressed in enteric bacterial systems.
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Construction of validated, non-redundant composite protein sequence databases.
Alan J. Bleasby,John C. Wootton +1 more
TL;DR: The modular nature of the integration process greatly facilitates the frequent updating of OWL following releases of the source databases, and the extent of redundancy in these sources is revealed by the comparison process.
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Nucleotide sequence, organisation and structural analysis of the products of genes in the nirB–cysG region of the Escherichia coli K-12 chromosome
Timothy Peakman,Joel Crouzet,Jean Francois Mayaux,Stephen J. W. Busby,Sudesh B. Mohan,Nerina Harborne,John C. Wootton,Rachel Nicolson,Jeffrey A. Cole +8 more
TL;DR: The DNA sequence and derived amino-acid sequence of a 5618-base region in the 74-min area of the Escherichia coli chromosome has been determined in order to locate the structural gene, nirB, for the NADH-dependent nitrite reductase and a gene, cysG, required for the synthesis of the sirohaem prosthetic group.