J
John J. P. Brevé
Researcher at VU University Medical Center
Publications - 42
Citations - 1196
John J. P. Brevé is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Tissue transglutaminase & Lymph. The author has an hindex of 19, co-authored 37 publications receiving 1086 citations. Previous affiliations of John J. P. Brevé include VU University Amsterdam.
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Journal ArticleDOI
Site-specific modulation of LPS-induced fever and interleukin-1β expression in rats by interleukin-10
Annemarie Ledeboer,R. Binnekade,John J. P. Brevé,John G.J.M. Bol,F. J. H. Tilders,Anne-Marie van Dam +5 more
TL;DR: It is concluded that IL-10 modulates the febrile response by acting in the periphery or in the brain dependent on the primary site of inflammation and that its mechanism of action most likely involves inhibition of local IL-1 beta production.
Journal ArticleDOI
Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb.
Anne Vroon,Benjamin Drukarch,John G.J.M. Bol,Patrick Cras,John J. P. Brevé,Stuart M. Allan,Jane K. Relton,Piet V.J.M. Hoogland,Anne Marie Van Dam +8 more
TL;DR: It is suggested that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD.
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In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET
Marloes Hagens,Sandeep S.V. Golla,Martijn T. Wijburg,Maqsood Yaqub,Dennis Heijtel,Dennis Heijtel,Martijn D. Steenwijk,Patrick Schober,John J. P. Brevé,Robert C. Schuit,Tristan A. Reekie,Michael Kassiou,Anne-Marie van Dam,Albert D. Windhorst,Joep Killestein,Frederik Barkhof,Frederik Barkhof,Bart N.M. van Berckel,Adriaan A. Lammertsma +18 more
TL;DR: The TSPO radioligand [18F]DPA714 can reliably identify increased focal and diffuse neuroinflammation in progressive MS when using plasma input-derived binding potential, but observed differences were predominantly visible in high-affinity binders.
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Cerebral microdialysis of interleukin (IL)-1ß and IL-6: extraction efficiency and production in the acute phase after severe traumatic brain injury in rats
Hedy Folkersma,John J. P. Brevé,F. J. H. Tilders,Leela Cherian,Claudia S. Robertson,W. Peter Vandertop +5 more
TL;DR: Cerebral microdialysis allows measurement of cytokine secretion in the ECF of brain tissue in rats, and in vivo determination of the temporal profile of extracellular fluid cytokines after severe TBI in rats is determined.
Journal Article
Alveolar macrophages down-regulate local pulmonary immune responses against intratracheally administered T-cell-dependent, but not T-cell-independent antigens.
TL;DR: The alveolar macrophages do not down-regulate the response against intratracheally administered T-cell-independent antigens, although they are important in the protection against inflammatory damage caused by bacterial endotoxins.