J
John L. Gollan
Researcher at Harvard University
Publications - 10
Citations - 3306
John L. Gollan is an academic researcher from Harvard University. The author has contributed to research in topics: Bilirubin diglucuronide & Bilirubin. The author has an hindex of 7, co-authored 10 publications receiving 3174 citations. Previous affiliations of John L. Gollan include Brigham and Women's Hospital.
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Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
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Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport.
TL;DR: It is postulate that cotransport of micelle-forming bile salts and lipids destined for biliary excretion, via an intracellular vesicular pathway, forms the basis for this microtubule dependence in bile salt-depleted and basal animals.
Journal Article
Increased expression of human ribosomal phosphoprotein P0 messenger RNA in hepatocellular carcinoma and colon carcinoma
Graham F. Barnard,Raymond J. Staniunas,Shideng Bao,Ken Ichi Mafune,Glenn Steele,John L. Gollan,Lan Bo Chen +6 more
TL;DR: Findings support a common increased expression of selected gene products in different tumors of endodermal origin and suggest that increased P0 expression, in line with certain other ribosomal proteins, may be associated with human colorectal cancer progression and biological aggressiveness.
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Cirrhosis as a consequence of graft-versus-host disease.
TL;DR: A 28-yr-old woman with severe idiopathic aplastic anemia received an HLA-identical mixed lymphocyte culture nonreactive bone marrow transplant from her brother and developed cutaneous and hepatic graft-versus-host disease, associated with marked cholestatic jaundice, which led to her eventual death.
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Regulation of bilirubin glucuronide synthesis in primate (Macaca fascicularis) liver. Kinetic analysis of microsomal bilirubin uridine diphosphate glucuronyltransferase.
Stephen C. Hauser,Stephen C. Hauser,Julia C. Ziurys,Julia C. Ziurys,John L. Gollan,John L. Gollan +5 more
TL;DR: It is demonstrated that microsomal bilirubin UDP-glucuronyltransferase has a greater capacity for BMG than BDG synthesis, and thus support the concept that the decreased BDG/BMG ratio in the bile of patients with reduced hepatic enzyme activity reflects the diminished capacity of the enzyme to synthesize BDG from BMG.