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Showing papers in "Gastroenterology in 1986"


Journal ArticleDOI
TL;DR: It is demonstrated that bacterial contamination of pancreatic necrosis occurs early and frequently, causing a significant increase in morbidity and mortality, particularly when it develops in the initial stages of the attack.

890 citations


Journal ArticleDOI
TL;DR: It is concluded that peristaltic dysfunction occurs in a substantial minority of patients with peptic esophagitis and could contribute to increased esophageal exposure to refluxed acid material.

636 citations


Journal ArticleDOI
TL;DR: It is concluded that neither omeprazole nor ranitidine per se is likely to induce proliferation of enterochromaffinlike cells and that they are reversible.

489 citations


Journal ArticleDOI
TL;DR: Esophageal balloon distention may provide a nonpharmacologic provocative test for esophageAL chest pain; and the mechanism of chest pain in patients with noncardiac chest pain may be related to lower pain threshold to Balloon distention, which is independent of esophagal contractions.

390 citations


Journal ArticleDOI
TL;DR: Serum alpha-fetoprotein levels were generally low, rarely assisted in diagnosis, but tended to increase when the mass attained a diameter of greater than 3 cm; sudden acceleration in the rate of increase in alpha- Fetoprotein level often coincided with a change of ultrasonic pattern to the massive one.

389 citations


Journal ArticleDOI
J.E. Kellow1, Thomas J. Borody1, Sidney F. Phillips1, R. L. Tucker1, A.C. Haddad1 
TL;DR: Motility varied widely between and within individuals, and differences between normal patterns in the jejunum and ileum were particularly striking, suggesting levels of recordings must be defined accurately if putative abnormalities, of possible clinical significance, are to be interpreted correctly.

364 citations


Journal ArticleDOI
TL;DR: It is concluded that pyloric dysmotility forms part of the widespread disruption of gut motility that affects some patients with diabetes.

360 citations


Journal ArticleDOI
TL;DR: A positive HBV-DNA test in anti-HBe carriers is associated with a severe and evolutive liver disease and may provide an indication for treatment with drugs inhibiting the synthesis ofHBV- DNA.

330 citations


Journal ArticleDOI
TL;DR: To assess the risk of development of spontaneous bacterial peritonitis in relation to the ascitic fluid total protein concentration, routine admission abdominal paracentesis was performed on a group of 107 patients during 125 hospitalizations.

313 citations


Journal ArticleDOI
TL;DR: A combination of alpha-fetoprotein and ultrasonography surveillance in patients with chronic hepatitis is recommended in order to improve the chance of early HCC detection as well as the chance for successful resection.

304 citations


Journal ArticleDOI
TL;DR: The data indicate that oxygen-derived free radicals play a role in ischemic injury to the stomach and that the hydroxyl radical, a secondary radical produced from the superoxide anion, appears to be the major oxygen radical contributing to isChemic damage.

Journal ArticleDOI
TL;DR: The authors thank E. Donnall Thomas for his constant encouragement; Derek Jewell for his gift of time; Kathleen McDonald for her editing skills; and Barbara Hicks, Patricia Jenkins, and Maxine Cormier for their help in typing the manuscript.

Journal ArticleDOI
TL;DR: Indium 111-granulocyte scans are a rapid, accurate, noninvasive means of assessing both disease extent and severity of colonic involvement in inflammatory bowel disease.

Journal ArticleDOI
TL;DR: Luminal prostaglandin E2 and leukotriene B4 levels may prove more useful predictors of the outcome of treatment in relapsing ulcerative colitis than clinical indices of disease activity.

Journal ArticleDOI
TL;DR: Data are consistent with the hypothesis that the gastric stasis in gut dysmotilities occurs because of impaired antral peristalsis due to antral hypomotility or increased resistance to flow into the small bowel due to intestinal dysmotility.

Journal ArticleDOI
TL;DR: Results indicate that capsaicin-sensitive afferent neurons are involved in gastric mucosal protection against ulcerogenic factors, and suggest that this type of gastric defense is primarily due to a local mechanism initiated by sensory nerve endings in the gastrics mucosa.

Journal ArticleDOI
TL;DR: The hypothesis that xanthine oxidase is a major source of oxygen-free radicals produced during reperfusion of the ischemic small bowel is supported.

Journal ArticleDOI
TL;DR: Five cases of an adenomatous hyperplastic nodule or a similar lesion resected from a cirrhotic liver in which early malignant foci were seen as small nodule-in-nodule lesions seem to represent an early stage of hepatocarcinogenesis in humans.

Journal ArticleDOI
TL;DR: Sixty patients with anginalike chest pain of noncardiac origin were studied to determine the diagnostic value of 24-h ambulatory esophageal pH and pressure monitoring and the results showed the esophagus to be the likely cause of the pain in 35% of the patients.

Journal ArticleDOI
TL;DR: It is proposed that a fraction of nor-UDC is secreted into canalicular bile in the unconjugated form and is protonated by a hydrogen ion derived from carbonic acid that was generated by the hydration of luminal CO2 by carbonic anhydrase present in biliary ductular cells.

Journal ArticleDOI
TL;DR: The conclusion that human gastric lipase shows no intrinsic specificity for short-chain triacylglycerols and that its apparent specificity is modulated by pH and presence of amphiphile in the incubation medium supports the view that, in the human, gastriclipolysis may play an important role in long-chain fat digestion.

Journal ArticleDOI
TL;DR: It is found that discussing appetizing food for 30 min (without sight, smell, or taste) increased acid secretion from 4 to 13 mmol/h in healthy human subjects and also increased serum gastrin concentrations significantly (p less than 0.001).

Journal ArticleDOI
TL;DR: It is concluded that essential dyspepsia patients who present for investigation with symptoms are more likely to be persistently neurotic, anxious, and depressed than dyspepsy-free controls, and this is unrelated to the presence of symptoms, but the association may not be of major clinical significance.

Journal ArticleDOI
TL;DR: It is suggested that the transverse colon, not the cecum and ascending colon, may be the primary site for fecal storage and may provide a useful tool for evaluating normal and abnormal large intestinal physiology.

Journal ArticleDOI
TL;DR: This study validates the endoscopic identification of a visible vessel in a gastric ulcer, and confirms that such identification has a high predictive value for the development of recurrent hemorrhage.

Journal ArticleDOI
TL;DR: In ilea of spontaneously infested guinea pigs, the interface between the plasma membranes of cryptosporidia and absorptive cells is examined and it is suggested that Cryptosporidial antigens may be sampled by intestinal lymphoid cells at sites underlying M cells.


Journal ArticleDOI
TL;DR: The initial endoscopic findings are of prognostic value in reflux esophagitis and smoking did not influence recurrence, and low-dose maintenance treatment with ranitidine does not prevent relapse.

Journal ArticleDOI
TL;DR: Results indicate that in patients with sludge the gallbladder is abnormal, showing mucus hypersecretion and glandular metaplasia, which leads to an increase in the mucus content of gallbladders bile, which in turn may result in nucleation of cholesterol crystals and may be regarded as the embryonic stage of gallstone disease.

Journal ArticleDOI
TL;DR: It is concluded that endoscopic polypectomy is adequate therapy for colonic polyps containing invasive carcinoma, provided that the favorable histologic features are present.