Showing papers in "Journal of Lipid Research in 1988"

TL;DR: Changes in postprandial cholesterolemia was inversely correlated with fasting levels of HDL cholesterol levels, and positively correlated with age.

TL;DR: In conclusion, inhibition of acyl-CoA:1,2-diacylglycerol O-acyltransferase (EC 2.3.1.20) by eicosapentaenoic acid may be important for reduced synthesis and secretion of triacyl glycerol from the liver.

TL;DR: It is concluded, from the various indicators proposed to monitor whole-body cholesterol synthesis, that the lathosterol/cholesterol ratio in serum appears preferable with respect to indicative power and ease of quantitation.

TL;DR: The results suggest that chronic (but not acute) intake of fish oil may inhibit the synthesis or secretion of chylomicrons from the gut, however, accelerated clearance due to decreased VLDL competition cannot be excluded.

TL;DR: It is shown that incubation of LDL with purified soybean lipoxygenase, in the presence of pure phospholipase A2, can mimic endothelial cell-induced oxidative modification, and represents the first example of oxidative modification of LDL by specific enzymes leading to enhanced recognition by macrophages.

TL;DR: The data suggest that plant sterols displace cholesterol from bile salt (taurocholate) micelles and that sitosterol is more effective than fucosterol in this capacity.

TL;DR: The results of the present study suggest that the air-exposed culture model, in which the keratinocytes show a high extent of stratification, could be of great value in the study of epidermal lipid metabolism, however, further alterations in culture conditions are necessary to more closely approximate the lipid composition of noncultured epidermis.

TL;DR: It is proposed that only a single copy of B-48 is required for V LDL assembly in rat liver, unless nascent hepatic VLDL contain additional apoB peptides which are uniformly lost from the plasma VLDl particles when they are analyzed.

TL;DR: It appears that ketoconazole inhibits cholesterol elimination as bile acids by blocking 14 alpha-demethylation, which results in effective drainage of sterol nucleus as lanosterols into bile and feces, which is associated with a marked reduction in low density lipoprotein (LDL) cholesterol level probably through activation of hepatic LDL apoB receptors.

TL;DR: The common phospholipids from biological sources were quantitated using phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy in conjunction with an analytical reagent composed of two parts: 1) 2 ml of reagent chloroform in which was dissolved 0.01-100 mg of crude tissue lipid extracted from tissue sources using chloro Form 2:1, the extract having been washed with 0.2 vol.

TL;DR: This review focuses on relatively common genetic differences rather than rare mutations, since animals provide useful models for the genetic control of lipoprotein metabolism, results from animal and human studies have been integrated.

TL;DR: The data may be interpreted to suggest that microheterogeneity in the physicochemical properties of human LDL subspecies reflects dissimilarities in their origins, intravascular metabolism, tissular fate, and possibly in their atherogenicity.

TL;DR: Assuming that plasma TRL containing apoB-100 are predominantly derived from the liver, the data suggest that triglyceride-rich lipoproteins from both the liver and intestine make a significant contribution to postprandial triglyceridemia

TL;DR: Results show that this phospholipid transfer protein is unique from the human plasma cholesteryl ester transfer protein, and may play an important role in human lipoprotein lipid metabolism.

TL;DR: The results raise the possibility that DHA may, in certain circumstances, promote tight, regular acyl chain packing arrays in DHA-rich membranes.

TL;DR: Brightness-discrimination learning ability was determined to be the highest in the perilla oil-fed group, followed by the normal group, and then by the safflower group, extending earlier observation in a different strain of rat that alpha-linolenic acid is a factor in maintaining high learning ability.

TL;DR: The successful testing of a synthetic lung surfactant consisting of a lipid-bound protein isolated from natural lung suractant and the lipids present in the "artificial" lung surfactor and now used in the same concentration but in a synthetic, commercially available form is reported on.

TL;DR: The specificity of the methylation reaction for NEFA without hydrolysis of other classes of plasma lipids was substantiated with appropriate standards and this one-step specific methylation procedure is superior to currently used methods.

TL;DR: Hepatic lipase appears to be essential for the conversion of small very low density and intermediate density particles to low density lipoproteins, and the pathways of direct plasma catabolism of these species were not affected by the enzyme defect.

TL;DR: It seems clear that the low density lipoproteins are important in initiation and exacerbation of coronary artery atherosclerosis in the experimental primate model as well as in man.

TL;DR: It is concluded that human liver-derived cells can secrete distinct VLDL and LDL-like particles, and the relative amounts of these lipoproteins are determined, at least in part, by the availability of free fatty acid.

TL;DR: The data suggest that even very low density lipoproteins with diameters smaller than 75 nm were practically excluded from entering the arterial wall, adding further support to the hypothesis that hypertriglyceridemic, diabetic cholesterol-fed rabbits are protected against atherogenesis.

TL;DR: It is proposed that methionine oxidation introduces hydrophilic residues at the nonpolar face of the amphipathic helical domains of these apolipoproteins and, therefore, alters their secondary structure and lipid affinity.

TL;DR: Results support the idea that beta 1- as well as beta 2-adrenergic receptors are coupled with adenylate cyclase and involved in the induction of lipolysis and represent a valuable tool for the quantification and the delineation of beta-receptor subtypes.

TL;DR: It is postulate that cotransport of micelle-forming bile salts and lipids destined for biliary excretion, via an intracellular vesicular pathway, forms the basis for this microtubule dependence in bile salt-depleted and basal animals.

TL;DR: The intestinal absorption of cholesterol and sitosterol was compared in rats and differences were seen when brush border membranes were incubated in vitro with micellar solutions containing either 50 microM [3H]cholesterol or [14C]sitosterol and the relative uptake of each sterol was unaffected by micellary phospholipid type.

TL;DR: Shifts in staining patterns, and staining intensity occurring during development may be related to variations in dietary fat intake, rates of cell proliferation, intestinal anatomy, and mechanisms for fat absorption.

TL;DR: The modified Recalde method does not require the expensive or complicated equipment required for elutriation and permits the isolation of human monocytes for culture in autologous serum from multiple donors in a single day.

TL;DR: It can be concluded that alpha-linolenic acid does not inhibit chain elongation and desaturation of linoleic acid to arachidonic acid in man.