John McDonald

TL;DR: The present findings demonstrate that UFP-512 behaves as a highly potent and selective agonist at Dop receptors and corroborate the proposal that the selective activation of DOP receptors elicits robust anxiolytic- and antidepressant-like effects in rodents.

TL;DR: The results support the notion that CK1α is able to mediate GPCR phosphorylation in an agonist-dependent manner and that this may provide a novel mechanism for G PCRosphorylation.

TL;DR: The NET1 gene, but not opioid receptors, is expressed in breast adenocarcinoma cells and may facilitate their migration, implying that NET1 contributes to mediating the direct effect of morphine on breast cancer cell migration.

TL;DR: It is concluded that phosphorylation of the M3-muscarinic receptor on sites in the third intracellular loop by casein kinase 1α contributes to the mechanism of receptor activation of ERK-1/2 by working in concert with the diacylglycerol/PKC arm of the phospholipase C signaling pathway.

TL;DR: The anti-apoptotic response of the muscarinic receptor family was confined to the Gq/11-coupled members of this family and the conserved poly-basic region in the C-terminal tail of the M1, M3, and M5 receptors contributes to the ability of these receptors to mediate protection against apoptosis.