John P. Iredale

TL;DR: In this paper, an artificial induction of hepatic stellate cell (HSC) apoptosis in vivo can promote the resolution of liver fibrosis, and the authors provided methods for treating liver disease in a subject involving administration of an inducer of apoptosis which is capable of selectively inducing hepatic Stellate Cell apoptosis.

TL;DR: Antibody-mediated blockade of hepatocyte αvβ8 in vitro, with assessment of TGF-β signaling pathways by real-time quantitative PCR array, supported the hypothesis that integrin αv β8 inhibition alters hepatocyte TGF -β signaling toward a pro-regenerative phenotype.

TL;DR: This assay is a robust alternative to traditional ligand-binding assays for challenging protein targets, and it overcomes specific difficulties associated with isolating human KMO.

TL;DR: This structured approach; defining the needs and requirements of patients with nonmalignant terminal diseases, together with clinical and epidemiological studies that allow a plotting of illness trajectory, has been successfully deployed in the pulmonary and renal fields to provide evidence-based guidelines to trigger specific interventions and the institution of specific services and treatments as the patient deteriorates.