J
John P. Iredale
Researcher at University of Bristol
Publications - 221
Citations - 26200
John P. Iredale is an academic researcher from University of Bristol. The author has contributed to research in topics: Hepatic stellate cell & Fibrosis. The author has an hindex of 77, co-authored 221 publications receiving 23394 citations. Previous affiliations of John P. Iredale include University College London & University of Cambridge.
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Journal ArticleDOI
Matrix Stiffness Modulates Proliferation, Chemotherapeutic Response and Dormancy in Hepatocellular Carcinoma Cells
Joerg Schrader,Joerg Schrader,Timothy T. Gordon-Walker,Rebecca L. Aucott,Marielle Van Deemter,Alexander Quaas,Shaun V. Walsh,Daniel Benten,Stuart J. Forbes,Rebecca G. Wells,John P. Iredale +10 more
TL;DR: increasing matrix stiffness promotes proliferation and chemotherapeutic resistance, whereas a soft environment induces reversible cellular dormancy and stem cell characteristics in HCC, which has implications for both the treatment of primary HCC and the prevention of tumor outgrowth from disseminated tumor cells.
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The Bone Marrow Functionally Contributes to Liver Fibrosis
Francesco Paolo Russo,Malcolm R. Alison,Brian W. Bigger,Eunice Amofah,Aikaterini Florou,Farhana Amin,George Bou-Gharios,Rosemary Jeffery,John P. Iredale,Stuart J. Forbes +9 more
TL;DR: The BM contributes functionally and significantly to liver fibrosis and is a potential therapeutic target in Liver fibrosis, which should be vigilant for the possibility of enhanced organ fibrosis.
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Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.
Neil C. Henderson,Alison C. MacKinnon,Sarah L. Farnworth,Tiina Kipari,Christopher Haslett,John P. Iredale,Fu-Tong Liu,Jeremy Hughes,Tariq Sethi +8 more
TL;DR: It is demonstrated for the first time that galectin-3 expression and secretion by macrophages is a major mechanism linking macrophage to the promotion of renal fibrosis.
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Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling
David C. Hay,Judy Fletcher,Catherine Payne,John D. Terrace,Ronald C. J. Gallagher,Jan Snoeys,James R. Black,Davina Wojtacha,Kay Samuel,Zara Hannoun,A. Pryde,Celine Filippi,Ian Currie,Stuart J. Forbes,James A. Ross,Philip N. Newsome,John P. Iredale +16 more
TL;DR: The studies provide compelling evidence that Wnt3a signaling is important for coordinated hepatocellular function in vitro and in vivo and demonstrate that WNT3a facilitates clonal plating of hESCs exhibiting functional hepatic differentiation.
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Now There Are Many (Stages) Where Before There Was One: In Search of a Pathophysiological Classification of Cirrhosis
TL;DR: This position paper attempts to catalyze a reformulation of the concept of cirrhosis from a static to a dynamic one, creating a template for further refinement of this concept in the future.